Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease.

Stroke 1984 Nov-Dec;15(6):1012-6

Highly elevated concentrations of homocysteine measured as homocysteine or cysteine-homocysteine mixed disulfide (MDS) are found in plasma and urine in subjects with inherited abnormalities of the methionine metabolism. These subjects have a high incidence of arteriosclerotic vascular complications during childhood. Homocysteine causes endothelial cell injury and cell detachment that initiates the development of arteriosclerosis. The present study demonstrates a significantly elevated mean plasma MDS concentration in 19 patients with arteriosclerotic cerebrovascular disease compared to 17 controls. Our findings suggest that moderate homocysteinemia might be a risk factor for arteriosclerotic cerebrovascular disease.

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http://dx.doi.org/10.1161/01.str.15.6.1012DOI Listing
January 1985
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References

(Supplied by CrossRef)
Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis
McCully KS et al.
Am J Pathol 1969
Production of arteriosclerosis by homocysteinemia
McCully KS et al.
Am J Pathol 1970
Arteriosclerosis due to homocyst(e)inemia. Failure to reproduce the model in weanlings rabbits
Donahue S et al.
Am J Pathol 1974

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