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Gram-negative bacterial toe web infection: successful treatment with a new third generation cephalosporin.

Authors:
N F Eaglstein W M Marley N F Marley E W Rosenberg A D Hernandez

J Am Acad Dermatol 1983 Feb;8(2):225-8

Fifteen patients with gram-negative bacterial toe web infections were treated for 1 week with intramuscular cefoperazone, a broad-spectrum third generation cephalosporin. Initial bacterial cultures in eleven patients (73%) grew more than one gram-negative organism. Pseudomonas aeruginosa was the most frequent isolate. All bacteria isolated were sensitive to cefoperazone (Cefobid). Swelling, redness, and flow of exudate resolved within 1 week of antibiotic administration. By day 7 there was no evidence of inflammation, and denuded areas had begun to re-epithelialize. Side effects were mild and did not require cessation of therapy. This antibiotic causes rapid resolution of a disease which previously required prolonged hospitalizations.

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http://dx.doi.org/10.1016/s0190-9622(83)70028-9DOI Listing
February 1983

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