Hautarzt 1971 Dec;22(12):535-6
Infect Immun 1999 Sep;67(9):4352-9
Department of Oral Biology, School of Dentistry, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Porphyromonas gingivalis, a gram-negative, black-pigmented anaerobe, is among the microorganisms implicated in the etiology of adult periodontal disease. This bacterium possesses a number of factors, including hemagglutinins, of potential importance in virulence. Several hemagglutinin genes have been identified, cloned, and expressed in Escherichia coli. Read More
Invest Ophthalmol Vis Sci 1995 May;36(6):1056-66
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Purpose: This study was designed to investigate an animal model of uveitis that resembles anterior uveitis in humans after immunization with iris-ciliary body antigen.Methods: Male Lewis rats 6 to 8 weeks of age were immunized with the buffer- and detergent-insoluble bovine iris-ciliary body antigen mixed with complete Freund's adjuvant and pertussis toxin. Antigen was digested with various proteolytic enzymes and tested in different rodent strains for a uveitogenic response. Read More
Clin Exp Immunol 1992 May;88(2):307-12
Department of Immunology, United Medical School, London, UK.
We compared the time course of changes in serum levels of circulating immune complexes (CICs) and of IgG antibody after sensitization of albino Lewis and pigmented Lister strain rats with uveitogenic (retinal S-antigen) and non-uveitogenic (ovalbumin) protein antigens of comparable molecular weight. Normal levels of CICs were far lower in Lewis rats in which experimental autoimmune uveoretinitis (EAU) takes the form of a severe panuveitis, than in Lister rats, in which the disease is mild, focal, confined to the posterior segment, and of lower incidence. After sensitization with either S-antigen or ovalbumin, polyethylene-glycol-precipitable CIC (PEG-CIC) peaked and fell as IgG antibody levels rose in both rat strains. Read More
Invest Ophthalmol Vis Sci 1992 Mar;33(3):522-31
Department of Ophthalmology, University of Illinois, Chicago College of Medicine 60612.
The inflammatory response in endogenous uveitis or after anterior segment surgery was noted to be substantially greater in heavily pigmented eyes. Because varying amounts of melanin are released into the anterior chamber after intraocular inflammation, it was hypothesized that a proinflammatory effect of melanin might account for the enhanced inflammatory response in these eyes. To test this hypothesis, albino (BALB/c) or pigmented (C57BL/6) mice were challenged in the anterior chamber 2 weeks after a subcutaneous foot pad injection of horse serum or conalbumin dissolved in Freund's complete adjuvant. Read More
Ophthalmic Res 1986 ;18(1):15-20
Bilateral posterior uveo-retinitis was induced in 6 pigmented rabbits by unilateral subconjunctival injection of 50 micrograms of retinal soluble antigen (S-antigen) in complete Freund's adjuvant. Ultrastructurally the inflammation revealed four distinct phases of target cell destruction in the retina. Initially there was a coagulative necrosis of the outer segments of the photoreceptor cells, followed by phagocytosis of these outer segments by mononuclear cells. Read More