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JAMA 2022 08;328(7):663-671

University of Kansas School of Medicine, VA Medical Center, Kansas City, Kansas.

Importance: Barrett esophagus is characterized by the replacement of normal esophageal squamous cell epithelium with columnar metaplasia and affects approximately 5% of people in the US and approximately 1% worldwide. Approximately 3% to 5% of patients with Barrett esophagus will be diagnosed with esophageal adenocarcinoma in their lifetime.

Observations: Barrett esophagus affects approximately 2. Read More

Int J Surg Pathol 2022 Aug 9:10668969221117988. Epub 2022 Aug 9.

Department of General Surgery and Organs Transplantation, 9311Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.

Ciliated epithelial cells have been rarely observed in urothelium lined mucosa. Only extremely rare reports in the literature have described this phenomenon and no cases have been described in other sites than the male urethra. Herein, we illustrate the finding of ciliated pseudostratified columnar cells in the renal calyx mucosa adjacent to an area of urothelial invasive carcinoma in an 82 year-old man with previous history of nephrolithiasis. Read More

BMC Vet Res 2022 Aug 9;18(1):304. Epub 2022 Aug 9.

Veterinary Specialists Ireland, Clonmahon, Summerhill, Co., Meath, A83 EV27, Ireland.

Background: True congenital pancreatic cysts are a rare pathological process reported within feline and human literature. To date there has been no documented case of a true congenital cyst affecting a canine patient. The objective of this case report is to document the clinical findings, diagnostic investigations, surgical treatment, histopathological diagnosis and long-term outcome of a dog with a true pancreatic cyst. Read More

Front Cell Dev Biol 2022 19;10:894737. Epub 2022 Jul 19.

Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, China.

The Hippo pathway and its downstream effectors, the transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), control stem cell fate and cell proliferation and differentiation and are essential for tissue self-renewal and regeneration. YAP/TAZ are the core components of the Hippo pathway and they coregulate transcription when localized in the nucleus. The intestinal epithelium undergoes well-regulated self-renewal and regeneration programs to maintain the structural and functional integrity of the epithelial barrier. Read More

Hum Pathol 2022 Aug 1. Epub 2022 Aug 1.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address: