J Sci Med Lille 1972 Jun;90(6):271-5
J Dairy Sci 2016 Oct 10;99(10):8267-8281. Epub 2016 Aug 10.
Quality Milk Production Services, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
The purpose was to evaluate 2 intramammary treatments for mild-to-moderate cases of clinical mastitis in a noninferiority comparison. Noninferiority trials are intended to show whether a given treatment, hetacillin potassium, has at least comparable efficacy as the reference treatment, ceftiofur hydrochloride. Treatments can be deemed inferior to the reference treatment by an amount less than the margin of noninferiority, or inconclusive if the confidence interval crosses the margin of noninferiority. Read More
J Dairy Sci 2015 Mar 26;98(3):1856-61. Epub 2014 Dec 26.
Department of Population Health and Pathobiology and the Food Animal Residue Avoidance Depletion Program, College of Veterinary Medicine, North Carolina State University, Raleigh 27607. Electronic address:
Mastitis remains a critical disease in the dairy industry and the use of intramammary antibiotics plays a critical role in mastitis treatment. Hetacillin is currently approved as an intramammary antibiotic that is used to treat mastitis in dairy cows. It is approved for once a day administration and can be used for a total of 3 d. Read More
J Dairy Sci 2014 Sep 3;97(9):5426-36. Epub 2014 Jul 3.
Department of Dairy Science, University of Wisconsin, Madison 53706. Electronic address:
Antimicrobials are frequently used for treatment of bovine mastitis and few studies have examined modern treatment strategies on large US dairy farms. The objective of this study was to describe treatment practices for clinical mastitis occurring in cows on large dairy herds in Wisconsin. Treatments performed on 747 cows experiencing cases of mild, moderate, or severe symptoms of clinical mastitis were recorded on 51 Wisconsin dairy farms. Read More
J Dairy Sci 1999 Aug;82(8):1664-70
Quality Milk Promotion Services, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA.
Milk culture results were retrospectively reviewed from 9007 cases of subclinical mastitis affecting cows housed in dairy herds located in New York and northern Pennsylvania. Cases included in this analysis had at least one mastitis pathogen isolated from the initial milk sample, were recultured within 1 mo, had permanent cow identification, and had records of whether mastitis was treated with an antibiotic or no treatment at all. Overall bacteriological cure rate for 21 mastitis pathogens was 68% (6097 of 9007). Read More
J AOAC Int 1998 Sep-Oct;81(5):963-72
U.S. Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, Wyndmoor, PA 19038, USA.
Antibiotic residues above tolerance levels are not allowed in foods derived from farm animals. Microbial inhibition assays are used to screen antibiotics in U.S. Read More