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J Allergy Clin Immunol 2022 Jun 30. Epub 2022 Jun 30.

Sorbonne Université, Inserm, Childhood Genetic Disorders, Hôpital Armand-Trousseau, Paris, France; Département de Génétique Médicale, Assistance Publique-Hôpitaux de Paris, Hôpital Armand-Trousseau, Paris, France. Electronic address:

Background: Urticarial lesions are observed in both cutaneous and systemic disorders. Familial forms of urticarial syndromes are rare and can be encountered in systemic autoinflammatory diseases.

Objective: We sought to investigate a large family with dominantly inherited chronic urticarial lesions associated with hypercytokinemia. Read More

Taiwan J Obstet Gynecol 2022 Jul;61(4):596-600

Laboratory of Histology-Embryology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.

Objective: Endometrial cancer is a threat to women health worldwide. Cylindromatosis (CYLD) enzyme is a tumour suppressor, considered an effective prognostic marker in various malignancies, but its role in endometrial carcinoma is not fully elucidated. Here, we sought to estimate the prognostic value of CYLD expression in endometrial carcinoma. Read More

J Dermatol Sci 2022 Jun 17;106(3):181-188. Epub 2022 May 17.

Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. Electronic address:

Background: Keratinocytes are recipients of melanosomes. Although the chemical basis of melanogenesis is well documented, the molecular mechanism of melanosome transfer must be elucidated. TRPA1 is a member of the transient receptor potential A subfamily. Read More

Drug Res (Stuttg) 2022 Jul 30;72(6):312-318. Epub 2022 May 30.

Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Chemotherapy, which is one of the common treatments for osteosarcoma (OS), has many side effects and in some cases has low effectiveness due to chemoresistance, hence it is vital to study new therapies for OS. In this regard, we combined melatonin with cisplatin and evaluate their effect on MG63 OS cells. Since melatonin has anti-cancer properties, we hypothesized that its combination with cisplatin could increase the effectiveness of cisplatin. Read More

Oncotarget 2022 24;13:707-722. Epub 2022 May 24.

Department of Otolaryngology/Head and Neck Surgery, UNC, Chapel Hill, NC 27599, USA.

Evolving understanding of head and neck squamous cell carcinoma (HNSCC) is leading to more specific diagnostic disease classifications. Among HNSCC caused by the human papilloma virus (HPV), tumors harboring defects in are associated with improved clinical outcomes and maintenance of episomal HPV. TRAF3 and CYLD are negative regulators of NF-κB and inactivating mutations of either leads to NF-κB overactivity. Read More