Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

Relationships between childhood trauma and multiple sclerosis: A systematic review.

Authors:
Carri S Polick Scott R Polick Sarah A Stoddard

J Psychosom Res 2022 Sep 25;160:110981. Epub 2022 Jun 25.

University of Michigan, School of Nursing, Ann Arbor, MI, United States of America. Electronic address:

Objective: Adverse Childhood Experiences (ACEs), such as physical, emotional, and sexual abuse trigger inflammatory changes and have been associated with many causes of morbidity and mortality, including autoimmune diseases. Although Multiple Sclerosis (MS) is a debilitating neurological autoimmune disease, literature linking ACEs and MS is understudied. The aim of this review was to examine the 1) state of the literature, and 2) relationships between childhood adversity and the prevalence and physical clinical features of MS (e.g., age at onset, relapses, pain, fatigue, disability).

Methods: A comprehensive search was preformed through five databases and by hand using the ancestry and descendancy approach for connections to papers published through January 20th, 2022. Studies were screened by independent reviewers using Rayyan.ai, and critically appraised for both quality and reporting transparency.

Results: Twelve studies examined relationships between any ACE(s) and the prevalence or physical clinical features of MS. There was considerable variance in the measurement of stressors, confounders, and categorization of MS; however most studies (n = 10) demonstrated an association between ACEs and MS (alone or grouped with other similar diagnoses), or physical clinical features.

Conclusion: Although there are few studies in this area, it is of quickly growing interest. These results should be cautiously interpreted, yet highlight the need for continued work to disentangle and discern true associations.

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jpsychores.2022.110981DOI Listing
September 2022

Publication Analysis

Top Keywords

physical clinical
12
prevalence physical
8
clinical features
8
multiple sclerosis
8
relationships childhood
8
true associations
4
2022 studies
4
published january
4
january 20th
4
20th 2022
4
studies
4
independent reviewers
4
studies screened
4
screened independent
4
connections papers
4
reviewers rayyanai
4
rayyanai critically
4
critically appraised
4
papers published
4
hand ancestry
4

Keyword Occurance

Similar Publications

Variability in Normalization Methods of Surface Electromyography Signals in Eccentric Hamstring Contraction.

Authors:
Juan Guerrero-Henriquez Claudio Tapia Martin Vargas-Matamala

J Sport Rehabil 2022 Aug 17:1-6. Epub 2022 Aug 17.

Department of Rehabilitation and Human Movement Sciences, Faculty of Health Sciences, University of Antofagasta, Antofagasta,Chile.

Context: In human movement analysis, normalization of a surface electromyography signal is a crucial step; therefore, parameter selection for this procedure must be adequately justified. The aim of this research was to determine the variability of electromyography signals in eccentric hamstring contraction under different normalization parameters.

Design: Cross-sectional study. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

In vivo degradation forms, anti-degradation strategies, and clinical applications of therapeutic peptides in non-infectious chronic diseases.

Authors:
Yagmur Tasdemiroglu Robert G Gourdie Jia-Qiang He

Eur J Pharmacol 2022 Aug 15:175192. Epub 2022 Aug 15.

Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061, USA. Electronic address:

Current medicinal treatments for diseases comprise largely of two categories: small molecule (chemical) drugs (e.g., aspirin) and larger molecules (peptides/proteins, e. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Comparison of Clinical Outcomes Between Athletes With Immediate and Delayed Onset of Symptoms Following Sport-Related Concussion.

Authors:
Alicia M Trbovich Abigail Kirschler Jonathan Preszler Michael W Collins Anthony P Kontos

Clin J Sport Med 2022 Aug 18. Epub 2022 Aug 18.

UPMC Sports Medicine Concussion Program, Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and.

Objective: To compare characteristics and clinical outcomes of adolescent athletes with immediate and delayed onset of symptoms following sport-related concussion (SRC). A secondary objective was to describe the symptoms that are delayed and the timing of symptom onset.

Design: Prospective, repeated measures study. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Low normal FMR1 genotype in older adult women: Psychological well-being and motor function.

Authors:
Jessica Klusek Roger Newman-Norlund Amanda J Fairchild Sarah Newman-Norlund Sara Sayers Jill C Stewart Elizabeth Berry-Kravis Julius Fridriksson

Arch Gerontol Geriatr 2022 Aug 12;103:104789. Epub 2022 Aug 12.

Department of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Close-Hipp Building, 1705 College Street, Columbia, SC 29208, USA.

The FMR1 gene plays a key role in adult neurogenesis and neuroplasticity, and thus may contribute to age-related health in the population. The current study focused on the "low normal" FMR1 genotype, defined by lower-than-typical numbers of FMR1 CGG repeats (<26), as a potential genetic determinant of age-related health. We characterized the effect of the low normal FMR1 genotype on psychological well-being and motor function in a racially diverse non-clinical sample of older adult women. Read More

View Article and Full-Text PDF
August 2022
Similar Publications
}