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Int J Mol Sci 2022 Aug 2;23(15). Epub 2022 Aug 2.

Center of Excellence on Translational Research in Inflammation and Immunology (CETRII), Department of Microbiology, Chulalongkorn University, Bangkok 10330, Thailand.

Due to (i) the simultaneous presence of (ulcer-induced bacteria) and in the stomach and (ii) the possibility of prokaryotic-eukaryotic endosymbiosis (intravacuolar in the yeast cells) under stresses, we tested this symbiosis in vitro and in vivo. To that end, intravacuolar were induced by the co-incubation of with under several stresses (acidic pH, non--enrichment media, and aerobic environments); the results were detectable by direct microscopy (wet mount) and real-time polymerase chain reaction (PCR). Indeed, intravacuolar were predominant under all stresses, especially the lower pH level (pH 2-3). Read More

Turk J Gastroenterol 2022 Aug 10. Epub 2022 Aug 10.

Department of Physiology, Marmara University Faculty of Medicine, İstanbul, Turkey.

Background: Previous studies found metformin as an effective agent to suppress oxidative stress, inflammation, and apoptosis in various inflammatory diseases. The present study investigated the effect of metformin against 2 experimental gastric injury models in rats, using macroscopical, histopathological, biochemical, and immunostaining studies.

Methods: After 24 hours of fasting, male Sprague-Dawley rats (280-400 g) (n = 8 per group) received indomethacin (80 mg/kg; indo ulcer group) or absolute ethanol (5 mL/kg; ethanol ulcer group) or vehicle orally by gavage. Read More

Saudi J Gastroenterol 2022 Aug 8. Epub 2022 Aug 8.

Deparment of Gastroenterology, Dicle University School of Medicine, Diyarbakır, Turkey.

Background: To investigage the thiol and disulphide levels in Helicobacter pylori-positive patients with non-ulcer dyspepsia and investigate the change in these levels with eradication therapy.

Methods: This is a prospective observational study. A total of 320 patients diagnosed with dyspepsia according to Rome IV criteria were included in the study. Read More

Tissue Cell 2022 Aug 3;78:101885. Epub 2022 Aug 3.

Department of Physiology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey.

The apelin/APJ system, which has a widespread distribution in the body, is involved in the regulation of physiological and pathophysiological mechanisms such as regulation of blood pressure, stress response, immunological activities, obesity, diabetes, inflammation, and neurodegenerative diseases. Apelin also undertakes various tasks in the digestive system such as cell proliferation, secretion of hormones (eg. cholecystokinin and histamine), modulation of gastric and pancreatic secretions, and motility response. Read More

PLoS Negl Trop Dis 2022 Aug 8;16(8):e0010672. Epub 2022 Aug 8.

Department of Clinical Laboratory Science, Faculty of Medical Technology, Teikyo University, Tokyo, Japan.

Buruli ulcer is a chronic skin disease caused by a toxic lipid mycolactone produced by Mycobacterium ulcerans, which induces local skin tissue destruction and analgesia. However, the cytotoxicity pathway induced by mycolactone remains largely unknown. Here we investigated the mycolactone-induced cell death pathway by screening host factors using a genome-scale lenti-CRISPR mutagenesis assay in human premonocytic THP-1 cells. Read More