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Drug Deliv 2022 Dec;29(1):2469-2480

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Giza Governorate, Egypt.

Ischemic stroke accounts for about 87% of all strokes, causing long-term disability in adults, and is the second leading cause of death worldwide. In search of new therapeutic modalities, the use of neuroprotective agents loaded in nanocarriers to be delivered by noninvasive means (i.e. Read More

Pharmaceutics 2022 Jul 17;14(7). Epub 2022 Jul 17.

Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.

Nanomedicines have revolutionized the treatment of certain types of cancer, as is the case of doxil, liposomal formulation with doxorubicin encapsulated, in the treatment of certain types of ovarian cancer, AIDS-related Kaposi sarcoma, and multiple myeloma. These nanomedicines can improve the performance of conventional chemotherapeutic treatments, with fewer side effects and better efficiency against cancer. Although liposomes have been used in some formulations, different nanocarriers with better features in terms of stability and adsorption capabilities are being explored. Read More

Nanomaterials (Basel) 2022 Jul 8;12(14). Epub 2022 Jul 8.

Pharmacokinetic, Nanotechnology and Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, Centro de Investigación Lascaray Ikergunea, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.

Gene supplementation therapy with plasmid DNA (pDNA) represents one of the most promising strategies for the treatment of monogenic diseases such as Fabry disease (FD). In the present work, we developed a solid lipid nanoparticles (SLN)-based non-viral vector with a size below 100 nm, and decorated with galactomannan (GM) to target the liver as an α-Galactosidase A (α-Gal A) production factory. After the physicochemical characterization of the GM-SLN vector, cellular uptake, transfection efficacy and capacity to increase α-Gal A activity were evaluated in vitro in a liver cell line (Hep G2) and in vivo in an animal model of FD. Read More

J Phys Chem Lett 2022 Aug 24;13(30):6935-6943. Epub 2022 Jul 24.

Université Rennes 1, CNRS UMR 6226, Institut des Sciences Chimiques de Rennes, Avenue du général Leclerc, 35042 Rennes Cedex, France.

According to their high electron density and ultrasmall size, gold nanoclusters (AuNCs) have unique luminescence and photoelectrochemical properties that make them very attractive for various biomedical fields. These applications require a clear understanding of their interaction with biological membranes. Here we demonstrate the ability of the AuNCs as markers for lipidic bilayer structures such as synthetic liposomes and biological extracellular vesicles (EVs). Read More

Colloids Surf B Biointerfaces 2022 Jun 22;217:112653. Epub 2022 Jun 22.

Consiglio Nazionale delle Ricerche, Scienze e Tecnologie per l'Energia e la Mobilità Sostenibili (CNR-STEMS), Piazzale Tecchio, 80, 80125 Napoli, Italy.

Lipidic carriers are efficient vehicles preserving drugs during cell administration. Several production processes of lipidic nanoparticles were developed to reduce mean size at nanometric level, enhancing homogeneity and process replicability. However, lipidic aggregation has always been considered a huge drawback in terms of high polidispersity and instability. Read More