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JACC Cardiovasc Interv 2022 Aug;15(16):1664-1674

Cardiovascular Research Foundation, New York, New York, USA.

Background: The clinical course of patients with moderate aortic stenosis (AS) remains incompletely defined.

Objectives: This study sought to analyze the clinical course of moderate AS and compare it with other stages of the disease.

Methods: Multiple electronic databases were searched to identify studies on adult moderate AS. Read More

Sci Total Environ 2022 Aug 15:158045. Epub 2022 Aug 15.

School of Environment, State Key Joint Laboratory of Environment Simulation and Pollution Control, Tsinghua University, Beijing 100084, China; State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex, Beijing 100084, China; Beijing Laboratory of Environmental Frontier Technologies, School of Environment, Tsinghua University, Beijing 100084, China.

Progressively stringent regulations regarding vehicle emissions and fuel economy have spurred technology diversification in light-duty passenger vehicles (LDPVs). To assess the real-world emissions and fuel economy performances of hybrid electric vehicles (HEVs) compared to conventional internal combustion engine (ICE) vehicles, on-road measurements of ten gasoline, four diesel and six full hybrid LDPVs were performed using portable emissions measurement systems (PEMS) in Macao, China. The hot-running emission results indicate that the high emission risks of gasoline vehicles are associated with high mileage and old model years. Read More

Am J Manag Care 2022 Aug;28(8):374-380

Humana Healthcare Research Inc, 500 W Main St, Louisville, KY 40202. Email:

Objectives: To explore the associations among activation, physical activity, hemoglobin A1c (HbA1c), and healthy days in older adults with type 2 diabetes (T2D) who participated in wellness programs.

Study Design: Observational, longitudinal cohort study utilizing survey, claims, and wellness program data.

Methods: From January to May 2018, individuals enrolled in a commercial or Medicare Advantage and prescription drug plan with T2D (aged 55-89 years) and SilverSneakers or step count data were eligible. Read More

Hum Mol Genet 2022 Aug 18. Epub 2022 Aug 18.

Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL USA.

De novo deleterious and heritable biallelic mutations in the DNA binding domain (DBD) of the transcription factor deformed epidermal autoregulatory factor 1 (DEAF1) result in a phenotypic spectrum of disorders termed DEAF1-associated neurodevelopmental disorders (DAND). RNA-sequencing using hippocampal RNA from mice with conditional deletion of Deaf1 in the central nervous system indicate that loss of Deaf1 activity results in the altered expression of genes involved in neuronal function, dendritic spine maintenance, development, and activity, with reduced dendritic spines in hippocampal regions. Since DEAF1 is not a dosage-sensitive gene, we assessed the dominant negative activity of previously identified de novo variants and a heritable recessive DEAF1 variant on selected DEAF1-regulated genes in 2 different cell models. Read More

IEEE Trans Neural Syst Rehabil Eng 2022 Aug 18;PP. Epub 2022 Aug 18.

This article evaluates and compares the performance and perception of prosthetic devices based on different design principles, a traditional rigid gripper and an adaptable poly-articulated hand, in a pre- and post-training protocol with an individual with bilateral amputation. As a representative of the first class, we use commercial hands (Ottobock's MyoHand VariPlus Speed), which is a widely adopted model by prosthesis users worldwide. We compare these with two SoftHand Pro hands, which are experimental prototypes exhibiting 19 articulations actuated by one single motor, and are inspired by human hand motor control models. Read More