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J Pediatr 2022 Aug 9. Epub 2022 Aug 9.

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

The objective of this single-center cohort study was to characterize frequency, clinical characteristics, and molecular epidemiology of pediatric SARS-CoV-2 infection after vaccination. Between 5/15/2021 and 1/1/2022, 171 children experienced SARS-CoV-2 infection post-vaccination, 146 (86%) following Omicron variant predominance. Outcomes were generally mild and comparable before and after Omicron predominance. Read More

J Cardiopulm Rehabil Prev 2022 Aug 11. Epub 2022 Aug 11.

Toronto Lung Transplant Program, University Health Network, Toronto, Canada (Drs Wickerson, Rozenberg, and Singer); Departments of Physical Therapy (Wickerson) and Medicine (Drs Rozenberg and Singer), University of Toronto, Toronto, Canada; and School of Rehabilitation Therapy, Queen's University, Kingston, Canada (Dr Mathur).

Purpose: The aim of this study was to examine the change and relationship among quadriceps torque (QT) and physical function in adult lung transplant (LTx) patients undergoing rehabilitation.

Methods: A prospective study assessed 6-min walk test (6MWT) distance, QT, and Short Physical Performance Battery (SPPB) at the start of pre-habilitation and 10-12 wk post-LTx. Functional outcomes were examined for within-group differences for participants who completed center-based rehabilitation between September 2019 and March 2020 and participants who completed telerehabilitation ("telerehab") between March 2020 and June 2021 during COVID-19. Read More

Lancet Glob Health 2022 Sep;10(9):e1247-e1256

Division of Public Health Surveillance and Response, National Institute for Communicable Diseases, Division of the National Health Laboratory Services, Johannesburg, South Africa; Right to Care, Centurion, South Africa.

Background: Post COVID-19 condition (PCC), as defined by WHO, refers to a wide range of new, returning, or ongoing health problems in people who have had COVID-19, and it represents a rapidly emerging public health priority. We aimed to establish how this developing condition has affected patients in South Africa and which population groups are at risk.

Methods: In this prospective cohort study, we used the DATCOV national hospital surveillance system to identify participants aged 18 years or older who had been hospitalised with laboratory-confirmed SARS-CoV-2 infection in South Africa. Read More

Lancet Glob Health 2022 Sep;10(9):e1210-e1211

National Postgraduate Medical College, Nigeria; Department of Social and Behavioral Health, School of Public Health, University of Nevada, Reno, Reno, NV 89557, USA. Electronic address:

Immunity 2022 Jul 19. Epub 2022 Jul 19.

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.

Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and patients with various forms of immunodeficiencies. Impaired vaccine-induced cell-mediated immunity was observed in many immunocompromised patients, particularly in solid-organ transplant and chronic lymphocytic leukemia patients. Read More