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[Pathogenetic and clinical features of cerebral venous thrombosis].

Authors:
L V Timchenko O N Zhadan I V Gilevich T S Zaruba

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(6):139-144

Research Institute - Ochapovsky Regional Clinic Hospital No.1, Krasnodar, Russia.

Objective: To study the etiopathogenetic and clinical features of inpatients with venous thrombosis.

Material And Methods: The analysis of 25 medical cases of patients with venous thrombosis was performed.

Results: Cerebral venous thrombosis most often developed in females (88%), the average age was 36 years. The most frequent localization of thrombosis was observed in the transverse sinus, as independently (40%) and in combination with thrombosis of other sinuses. Headache was the main clinical sign that could be a single feature or accompanied by other neurological symptoms. In 13 patients (86.6%), multiple polymorphisms in blood coagulation genes (more than 4 mutations) were identified. All patients were prescribed anticoagulant therapy. In all cases, there were positive dynamics of the patients' condition, in the form of a decrease in the intensity of headache or complete regression of cephalalgia, neurological symptoms regressed in 20 patients (80%), there was no fatal outcome.

Conclusion: If central venous thrombosis is detected, especially in young people, an analysis for genetic polymorphism of the blood coagulation system and the folate cycle should be carried out. This will allow timely development of secondary prevention and reduce the risk of recurrent thrombosis.

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http://dx.doi.org/10.17116/jnevro2022122061139DOI Listing
June 2022

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