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Biochem Pharmacol 2022 Aug 7:115203. Epub 2022 Aug 7.

Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea. Electronic address:

Resolvin D3 (RD3), an endogenous lipid mediator derived from omega-3 fatty acids, has been documented to attenuate inflammation in various disease models. Although it has been reported that omega-3 fatty acids attenuate metabolic disorders, the roles of RD3 in insulin signaling in skeletal muscle and hepatic lipid metabolism remain unclear. In the current study, we examined the role of RD3 in skeletal muscle insulin resistance and hepatic steatosis using in vitro and in vivo obesity models. Read More

Chemosphere 2022 Aug 7:135977. Epub 2022 Aug 7.

Institute of Quality Standard and Testing Technology for Agro-Products, Hubei Academy of Agricultural Sciences, Hubei Key Laboratory of Nutritional Quality and Safety of Agro-products, Wuhan, 430064, Hubei, China.

Interactions between titanium dioxide nanoparticles (n-TiO) and pollutants in the aquatic environment may alter the bioavailability of pollutants, and thus altering their toxicity and fate. In order to investigate the bioconcentration of azoxystrobin (AZ) and its mechanism of cardiotoxicity in the presence of n-TiO, the experiment was divided into control, n-TiO (100 μg/L), AZ (40, 200 and 1000 μg/L) and AZ (40, 200, 1000 μg/L) + n-TiO groups, and the zebrafish embryos were exposed to the exposure solution until 72 h post-fertilization. Results suggested the presence of n-TiO notably reduced the accumulation of AZ in larvae compared with exposure to AZ alone, thereby significantly decreasing AZ-induced cardiotoxicity, including heart rate changes, pericardium edema, venous thrombosis, increased sinus venosus and bulbus arteriosus distance and changes in cardiac-related gene expression. Read More

Autophagy 2022 Aug 10. Epub 2022 Aug 10.

Institute for Research in Biomedicine (IRB Barcelona). The Barcelona Institute of Science and Technology, Barcelona, Spain.

Brown adipose tissue (BAT) thermogenesis affects energy balance, and thereby it has the potential to induce weight loss and to prevent obesity. Here we document a macroautophagic/autophagic-dependent mechanism of PPARG activity regulation that induces brown adipose differentiation and thermogenesis, and that is mediated by TP53INP2. Disruption of TP53INP2-dependent autophagy reduced brown adipogenesis in cultured cells. Read More

An Acad Bras Cienc 2022 8;94(2):e20210938. Epub 2022 Aug 8.

Tianjin University of Traditional Chinese Medicine, School of Integrative Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, China.

Triptolide is a natural active compound that has significant neuroprotective properties and shows promising effects in the treatment of Alzheimer's disease (AD). Recent studies have shown that autophagy occurs in AD. In this study, we determined whether autophagy regulated by triptolide ameliorates neuronal death caused by amyloid-Beta1-42 (Aβ1-42). Read More

Adipocyte 2022 Aug 10. Epub 2022 Aug 10.

University of Lyon, UMR Ecologie Microbienne Lyon (LEM), Research Team "Bacterial Opportunistic Pathogens and Environment" (BPOE), CNRS 5557, INRAE 1418, Université Claude Bernard Lyon 1, VetAgro Sup, 69622 Villeurbanne ou 69363 Lyon, France.

Metabolic disorders related to obesity are largely dependent on adipose tissue hypertrophy, which involves adipocyte hypertrophy and increased adipogenesis. Adiposize is regulated by lipid accumulation as a result of increased lipogenesis (mainly lipid uptake in mature adipocytes) and reduced lipolysis. Using realtime 2D cell culture analyses of lipid uptake, we show 1) that high glucose concentration (4. Read More