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Arthroscopy 2022 Aug 12. Epub 2022 Aug 12.

UCSF Department of Orthopedic Surgery, San Francisco, CA.

Purpose: To investigate the association between pre-operative mental health disorders and post-operative complications, readmissions, and ipsilateral revision procedures amongst patients undergoing arthroscopic rotator cuff repair (RCR).

Methods: A retrospective cohort study from 2010 to 2020 was performed using the PearlDiver database. Current Procedural Terminology (CPT) and International Classification of Diseases (ICD) codes were used to compare patients with and without mental health disorders who underwent arthroscopic RCR. Read More

J Affect Disord 2022 Aug 12. Epub 2022 Aug 12.

Otsuka Canada Pharmaceutical Inc., Saint-Laurent, QC, Canada; Department of Pharmacology & Therapeutics, Faculty of Medicine and Health Sciences, McGill University, Montréal, QC, Canada.

Background: Major depressive disorder (MDD) is a clinically heterogenous condition and its treatment should be individualized according to the presence of particular symptom clusters. The aim of this pooled analysis was to investigate the effects of adjunctive brexpiprazole on different symptom clusters in MDD.

Methods: Data were included from four similarly designed, short-term, randomized, double-blind, placebo-controlled studies of adjunctive brexpiprazole in adults with MDD and inadequate response to 2-4 antidepressant treatments (ADTs), including 1 administered by investigators. Read More

J Psychiatr Res 2022 Jul 31;155:1-9. Epub 2022 Jul 31.

Health Sciences Postgraduate Program, Health Sciences Center, State University of Londrina (UEL), Londrina, Paraná, Brazil; Department of Clinical Medicine, Psychiatry Unit, Health Sciences Center, State University of Londrina, (UEL), Londrina, Paraná, Brazil.

Elevated C-reactive protein (CRP) levels were associated with cognitive decline, sedentary behaviour, and childhood trauma in patients with major affective disorders. This study aims to examine the association of peripheral CRP levels, cognitive function, childhood trauma, sedentary behaviour, and quality of life in individuals with major affective disorders, including bipolar disorder (BD), major depressive disorder (MDD), and individuals without mood disorders (controls). We included outpatients with BD (n = 42), MDD (n = 27), and healthy controls (n = 40). Read More

Eur Eat Disord Rev 2022 Aug 15. Epub 2022 Aug 15.

Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, USA.

Background: Integrative Cognitive Affective Therapy (ICAT) is an empirically supported treatment for bulimia nervosa (BN) in adults. However, it is unclear whether a modified version, Integrative Cognitive Affective Therapy-Adolescent (ICAT-A) is feasible and beneficial for adolescents. This study evaluated the feasibility of ICAT-A for adolescents with BN or subthreshold BN. Read More

JMIR Ment Health 2022 Aug 15;9(8):e38934. Epub 2022 Aug 15.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Background: Remote measurement technologies, such as smartphones and wearable devices, can improve treatment outcomes for depression through enhanced illness characterization and monitoring. However, little is known about digital outcomes that are clinically meaningful to patients and clinicians. Moreover, if these technologies are to be successfully implemented within treatment, stakeholders' views on the barriers to and facilitators of their implementation in treatment must be considered. Read More