Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

Smart Peptide Defense Web In Situ Connects for Continuous Interception of IgE against Allergic Rhinitis.

Authors:
Meng-Ru Ding Qi-Lin Liang Huan-Ge Xu Xiang-Dan Li Kuo Zhang Zi-Jin Wei Yong-Hong Gao Qing-Shi Zhang Rui Huang Huai Yang Lei Wang Hao Wang

ACS Appl Mater Interfaces 2022 Jul 24;14(26):29639-29649. Epub 2022 Jun 24.

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 100190, P. R. China.

Allergic rhinitis (AR) is a chronic inflammatory reaction by immunoglobulin E (IgE) mediators after individual contact with allergens. It affects 10-40% of the world's population and reduces the quality of life. Long-term symptoms of rhinitis can cause inflammation to spread and trigger asthma, which can harm human health. Herein, we develop a mart eptde defese (SPIN) web technique, which in situ constructs a peptide web, trapping IgE against AR. Two candidate SPINs, SPIN-1 and SPIN-2, are designed with different IgE-binding sequences. The SPIN-1 or SPIN-2 is able to bind to IgE and transform from nanoparticles into entangled nanofibers. In turn, the web of SPIN-1 or SPIN-2 acts as a long-term trap of IgE to prevent the IgE from binding to mast cells. SPIN-1 or SPIN-2 (10 mg/kg) is able to treat AR model Balb/c mice with high efficiency and reduced symptoms of rhinitis and inflammatory factors, even better than a first-line clinical drug, cetirizine (10 mg/kg). For example, the amount of IL-4 released in the AR group (185.5 ± 6.8 pg/mL) is significantly reduced after the treatment with SPIN-1 (70.4 ± 14.1 pg/mL), SPIN-2 (86.0 ± 9.3 pg/mL), or cetirizine (112.8 ± 19.3 pg/mL). More importantly, compared with the cetirizine group (1 day), the SPIN-1 or SPIN-2 group shows long-term therapeutic effects (1 week). The SPIN web technique shows the great potential for blocking IgE binding to mast cells in vivo, attenuating AR or other allergic reactions.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.2c07092DOI Listing
July 2022

Publication Analysis

Top Keywords

spin-1 spin-2
20
ige binding
8
symptoms rhinitis
8
binding mast
8
mast cells
8
allergic rhinitis
8
spin web
8
web technique
8
ige
7
spin-1
6
spin-2
6
web
5
efficiency reduced
4
high efficiency
4
reduced symptoms
4
prevent ige
4
rhinitis inflammatory
4
inflammatory factors
4
balb/c mice
4
model balb/c
4

Keyword Occurance

Similar Publications

Smart Peptide Defense Web In Situ Connects for Continuous Interception of IgE against Allergic Rhinitis.

Authors:
Meng-Ru Ding Qi-Lin Liang Huan-Ge Xu Xiang-Dan Li Kuo Zhang Zi-Jin Wei Yong-Hong Gao Qing-Shi Zhang Rui Huang Huai Yang Lei Wang Hao Wang

ACS Appl Mater Interfaces 2022 Jul 24;14(26):29639-29649. Epub 2022 Jun 24.

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 100190, P. R. China.

Allergic rhinitis (AR) is a chronic inflammatory reaction by immunoglobulin E (IgE) mediators after individual contact with allergens. It affects 10-40% of the world's population and reduces the quality of life. Long-term symptoms of rhinitis can cause inflammation to spread and trigger asthma, which can harm human health. Read More

View Article and Full-Text PDF
July 2022
Similar Publications

Gravitational Perturbations of Rotating Black Holes in Lorenz Gauge.

Authors:
Sam R Dolan Chris Kavanagh Barry Wardell

Phys Rev Lett 2022 Apr;128(15):151101

School of Mathematics and Statistics, University College Dublin, Belfield, Dublin 4, Ireland.

Perturbations of Kerr spacetime are typically studied with the Teukolsky formalism, in which a pair of gauge invariant components of the perturbed Weyl tensor are expressed in terms of separable modes that satisfy ordinary differential equations. However, for certain applications it is desirable to construct the full metric perturbation in the Lorenz gauge, in which the linearized Einstein field equations take a manifestly hyperbolic form. Here we obtain a set of Lorenz-gauge solutions to the linearized vacuum field equations on Kerr-Newman-Unti-Tamburino spacetimes in terms of homogeneous solutions to the spin-2, spin-1, and spin-0 Teukolsky equations. Read More

View Article and Full-Text PDF
April 2022
Similar Publications

Quench Dynamics of Collective Modes in Fractional Quantum Hall Bilayers.

Authors:
Zhao Liu Ajit C Balram Zlatko Papić Andrey Gromov

Phys Rev Lett 2021 Feb;126(7):076604

Brown Theoretical Physics Center and Department of Physics, Brown University, 182 Hope Street, Providence, Rhode Island 02912, USA.

We introduce different types of quenches to probe the nonequilibrium dynamics and multiple collective modes of bilayer fractional quantum Hall states. We show that applying an electric field in one layer induces oscillations of a spin-1 degree of freedom, whose frequency matches the long-wavelength limit of the dipole mode. On the other hand, oscillations of the long-wavelength limit of the quadrupole mode, i. Read More

View Article and Full-Text PDF
February 2021
Similar Publications

In the Model Host , Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria.

Authors:
Kiho Lee Iliana Escobar Yeeun Jang Wooseong Kim Frederick M Ausubel Eleftherios Mylonakis

Int J Mol Sci 2020 Oct 22;21(21). Epub 2020 Oct 22.

Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.

Sphingosine-1-phophate (S1P) is a sphingolipid-derived signaling molecule that controls diverse cellular functions including cell growth, homeostasis, and stress responses. In a variety of metazoans, cytosolic S1P is transported into the extracellular space where it activates S1P receptors in a concentration-dependent manner. In the free-living nematode , the gene, which encodes a S1P transporter, is activated during Gram-positive or Gram-negative bacterial infection of the intestine. Read More

View Article and Full-Text PDF
October 2020
Similar Publications

Longitudinal and transverse electron paramagnetic resonance in a scanning tunneling microscope.

Authors:
Tom S Seifert Stepan Kovarik Dominik M Juraschek Nicola A Spaldin Pietro Gambardella Sebastian Stepanow

Sci Adv 2020 Sep 30;6(40). Epub 2020 Sep 30.

Department of Materials, ETH Zürich, 8093 Zürich, Switzerland.

Electron paramagnetic resonance (EPR) spectroscopy is widely used to characterize paramagnetic complexes. Recently, EPR combined with scanning tunneling microscopy (STM) achieved single-spin sensitivity with sub-angstrom spatial resolution. The excitation mechanism of EPR in STM, however, is broadly debated, raising concerns about widespread application of this technique. Read More

View Article and Full-Text PDF
September 2020
Similar Publications
}
© 2022 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap