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J Ethnopharmacol 2022 Aug 13:115642. Epub 2022 Aug 13.

Department of Biopharmaceuticals, School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:

Ethnopharmacological Relevance: Tubiechong comprises mainly Eupolyphaga and Steleophaga is widely distributed in China. It has been used in the traditional medicine systems in Asian countries specially in China，Japan and Singapore for thousand years.

Aim Of The Review: The aim of this work is to review the scientific work about Tubiechong regarding their ethnomedicinal uses, bioactive chemical constituents and pharmacological activities. Read More

J Colloid Interface Sci 2022 Aug 11;628(Pt B):53-63. Epub 2022 Aug 11.

Jiangsu Key Laboratory of New Power Batteries, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China. Electronic address:

Ultrathin nanoframes with more available electrocatalytic active sites on both internal and external surfaces have attracted great attention especially in the field of electrocatalysis. Herein, we report a facile process to prepare PdAu nanorings (NRs) in aqueous solution without adding any organic ligands. The growth mechanism of PdAu NRs was explored in detail. Read More

mSphere 2022 Aug 16:e0029022. Epub 2022 Aug 16.

Biocenter, Institute of Molecular Biology, Medical University of Innsbruck, Innsbruck, Austria.

Temporin B (TB) is a 13-amino-acid-long, cationic peptide secreted by the granular glands of the European frog Rana temporaria. We recently showed that the modified TB peptide analog TB_KKG6K rapidly killed planktonic and sessile Candida albicans at low micromolar concentrations and was neither hemolytic nor cytotoxic to mammalian cells . The present study aimed to shed light into its mechanism of action, with a focus on its fungal cell membrane activity. Read More

Nucleic Acids Res 2022 Aug 16. Epub 2022 Aug 16.

Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine.

Protein synthesis in eukaryotic cell is spatially and structurally compartmentalized that ensures high efficiency of this process. One of the distinctive features of higher eukaryotes is the existence of stable multi-protein complexes of aminoacyl-tRNA synthetases and translation elongation factors. Here, we report a quaternary organization of the human guanine-nucleotide exchange factor (GEF) complex, eEF1B, comprising α, β and γ subunits that specifically associate into a heterotrimeric form eEF1B(αβγ)3. Read More

Cryst Growth Des 2022 Aug 20;22(8):4696-4707. Epub 2022 Jul 20.

Centre for Sustainable and Circular Technologies (CSCT), University of Bath, Claverton Down, Bath BA2 7AY, U.K.

Salbutamol is an active pharmaceutical ingredient commonly used to treat respiratory distress and is listed by the World Health Organization as an essential medicine. Here, we establish the crystal structure of its oxalate form, salbutamol oxalate, and explore the nature of its crystallographic disorder by combined X-ray crystallography and C cross-polarization (CP) magic-angle spinning (MAS) solid-state NMR. The *C-OH chiral center of salbutamol (note that the crystal structures are a racemic mixture of the two enantiomers of salbutamol) is disordered over two positions, and the -butyl group is rotating rapidly, as revealed by C solid-state NMR. Read More