HPV and HIV Coinfection in Women from a Southeast Region of Romania-PICOPIV Study.

Authors:

Simona Claudia Cambrea Mariana Aschie Ghiulendan Resul Anca Florentina Mitroi Anca Chisoi Antonela Anca Nicolau Gabriela Izabela Baltatescu Ana Maria Cretu Gabriela Lupasteanu Lucian Serbanescu Mihaela Manea Sebastian Theodor Topliceanu Lucian Cristian Petcu Loredana Pazara Georgeta Camelia Cozaru

Medicina (Kaunas) 2022 Jun 3;58(6). Epub 2022 Jun 3.

Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Ovidius University of Constanta, 145 Tomis Blvd., 900591 Constanta, Romania.

: Romania faces one of the highest cervical cancer burdens in Europe though it is a preventable cancer through population screening by cytology and human papillomavirus (HPV) detection. Also, it has one of the highest incidences of human immunodeficiency virus (HIV) infection. HPV and HIV coinfection are frequently encountered. The aim of study was to establish the prevalence of HPV infection among HIV-positive women in Southeast Region of Romania, to genotype high risk HPV types -and to correlate the results with clinical data and cytological cervical lesions. : 40 HIV-positive women were screened for HPV types and for cytological cervical lesions. The findings were evaluated in correlation with CD4 cell counts, HIV viral load, age at first sexual intercourse, number of sexual partners, vaginal candidiasis, and Gardnerella using statistical methods. : 19/40 (47.5%) women were positive for HPV types, 63.15% infected with single HPV type and 36.85% with multiple HPV types. The most frequent types were type: 31 (42.1%), 56 (31.57%), 53 (15.78%). On cytology, 34 (85%) women were found with NILM of which 38.23% were HPV-positive. Fifteen percent of women had abnormal cytology (three ASC-US, three LSIL), and all of them were HPV-positive. Through analyzing the value of CD4 count, women with CD4 count ≤ 200 cells/μL were found to be significantly more likely to be infected with HPV; meanwhile there was no correlation between the detection of HPV types and HIV viral load. Candida or Gardnerella were more often associated with HIV-positive women with HPV, than in women without HPV. Infection with HPV types is common among HIV-positive women in the Southeast Region of Romania and it is associated with age at the beginning of sexual life, number of sexual partners, CD4 value, vaginal candidiasis, and Gardnerella infection.

Download full-text PDF	Source
http://dx.doi.org/10.3390/medicina58060760	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231193	PMC

June 2022

Publication Analysis

Top Keywords

candidiasis gardnerella

cd4 count

women hpv

hpv infection

Keyword Occurance

Similar Publications

Concordance of p16 and E6*I mRNA among HPV-DNA-Positive Oropharyngeal, Laryngeal, and Oral Cavity Carcinomas from the ICO International Study.

Cancers (Basel) 2022 Aug 4;14(15). Epub 2022 Aug 4.

Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO)-IDIBELL, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.

: Tests or test algorithms for diagnosing HPV-driven oral cavity and laryngeal head and neck carcinomas (HNC) have not been yet validated, and the differences among oral cavity and laryngeal sites have not been comprehensively evaluated. We aimed to assess the utility of a diagnostic algorithm for the detection of HPV-driven oral cavity (OCC), oropharyngeal (OPC) and laryngeal (LC) carcinomas using HPV-DNA testing followed by p16 immunohistochemistry, taking E6*I mRNA detection as the reference standard. Formalin-fixed paraffin-embedded OCC, OPC, and LC carcinomas were collected from pathology archives in 29 countries. Read More

View Article and Full-Text PDF

August 2022

Similar Publications

[[Translated article]]Changes in the Prevalence of Human Papillomavirus Genotypes in Genital Warts Since the Introduction of Prophylactic Vaccines.

Authors:

Jorge Magdaleno-Tapial Pablo Hernández-Bel José María Ortiz-Salvador Andrés Casanova-Esquembre Javier Lorca-Spröhnle Carolina Labrandero-Hoyos Rodrigo Peñuelas-Leal José Luis Sánchez-Carazo Amparo Pérez-Ferriols

Actas Dermosifiliogr 2022 Aug 8. Epub 2022 Aug 8.

Servicio de Dermatología, Hospital General Universitario de Valencia.

Background And Objective: Genital warts are caused by the human papillomavirus (HPV), whose genotypes have traditionally been classified as low risk or high risk (oncogenic). The first 2 prophylactic vaccines included the most common genotypes at the time: HPV-6, HPV-11, HPV-16, and HPV-18. The aim of this study was to evaluate the prevalence of HPV types in our setting 10 years after the introduction of HPV vaccines. Read More

View Article and Full-Text PDF

August 2022

Similar Publications

The HPV Induced Cancer Resource (THInCR): a Suite of Tools for Investigating HPV-Dependent Human Carcinogenesis.

Authors:

Mikhail Salnikov Steven F Gameiro Peter Y F Zeng John W Barrett Anthony C Nichols Joe S Mymryk

mSphere 2022 Aug 11:e0031722. Epub 2022 Aug 11.

Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada.

Human papillomaviruses (HPVs) are highly infectious and cause the most common sexually transmitted viral infections. They induce hyperproliferation of squamous epithelial tissue, often forming warts. Virally encoded proteins reprogram gene expression and cell growth to create an optimal environment for viral replication. Read More

View Article and Full-Text PDF

August 2022

Similar Publications

A systematic review of economic evaluations of cervical cancer screening methods.

Authors:

Thatohatsi Sefuthi Lungiswa Nkonki

Syst Rev 2022 Aug 9;11(1):162. Epub 2022 Aug 9.

Health Economics, Division of Health Systems and Public Health, Global Health Department, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.

Objective: The aims of this systematic review were to (1) identify primary- and model-based economic evaluations of cervical cancer screening methods and to (2) provide a contextual summary of valuation outcomes associated with three types of cervical cancer screening tests: visual inspection with acetic acid, human papillomavirus deoxyribonucleic acid, and Papanicolaou smear.

Introduction: Cervical cancer screening is an important public health priority with the potential to improve the detection of precancerous lesions in high-risk females for early intervention and disease prevention. Test performance and cost-effectiveness differ based on the specific screening method used across different platforms. Read More

View Article and Full-Text PDF

August 2022

Similar Publications

Immunogenicity, safety, and efficacy of the HPV vaccines among people living with HIV: A systematic review and meta-analysis.

Authors:

Lisa Staadegaard Minttu M Rönn Nirali Soni Meghan E Bellerose Paul Bloem Marc Brisson Mathieu Maheu-Giroux Ruanne V Barnabas Melanie Drolet Philippe Mayaud Shona Dalal Marie-Claude Boily

EClinicalMedicine 2022 Oct 3;52:101585. Epub 2022 Aug 3.

Department of Infectious Diseases Epidemiology, Imperial College, London, United Kingdom.

Background: Vaccines have been demonstrated to protect against high-risk human papillomavirus infection (HPV), including HPV-16/18, and cervical lesions among HIV negative women. However, their efficacy remains uncertain for people living with HIV (PLHIV).We systematically reviewed available evidence on HPV vaccine on immunological, virological, or other biological outcomes in PLHIV. Read More

View Article and Full-Text PDF

October 2022

Similar Publications

}

Search Our Scientific Publications & Authors