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Biomedicines 2022 Jun 8;10(6). Epub 2022 Jun 8.

BG Trauma Center Bergmannstrost, 06112 Halle (Saale), Germany.

Osteoarthritis (OA) alters chondrocyte metabolism and mitochondrial biology. We explored whether OA and non-OA chondrocytes show persistent differences in metabolism and mitochondrial function and different responsiveness to cytokines and cAMP modulators. Hip chondrocytes from patients with OA or femoral neck fracture (non-OA) were stimulated with IL-1β, TNF, forskolin and opioid peptides. Read More

J Orthop Surg Res 2022 Mar 5;17(1):148. Epub 2022 Mar 5.

Department of Orthopedics, The Third People's Hospital of Hefei, No. 204, Wangjiang East Road, Baohe District, Hefei, 230041, Anhui, China.

Background: MiR-146a has been widely studied in the pathogenesis of osteoarthritis (OA); however, the results are still controversial.

Objective: This meta-analysis analyzes the expression profile of miR-146a in various tissues of OA patients.

Methods: Public databases were searched for appropriate studies published up to September 1, 2021. Read More

Acta Histochem 2022 Apr 19;124(3):151867. Epub 2022 Feb 19.

Department of Anatomy, Research Block B, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address:

Objectives: Despite the presence of chondrogenic progenitor cells (CPCs) in knee osteoarthritis patients they are unable to repair the damaged cartilage. This study aimed to evaluate the oxidative stress, cellular senescence, and senescence-associated secretory phenotype (SASP) in the CPCs derived from osteoarthritic cartilage and compare with the CPCs of healthy articular cartilage.

Methods: Isolated CPCs were characterized based on phenotypic expression of stem cell markers, clonogenicity, and tri-lineage differentiation assay. Read More

Front Immunol 2021 27;12:722884. Epub 2021 Aug 27.

Department of Orthopaedic Surgery, Experimental Orthopaedics, Center for Medical Biotechnology, University of Regensburg, Regensburg, Germany.

Osteoarthritis (OA) is a degenerative joint disease that not only causes cartilage loss but also structural damage in all joint tissues. Joints are innervated by alpha-calcitonin gene-related peptide (αCGRP) and substance P (SP)-positive sensory nerve fibers. Alteration of sensory joint innervation could be partly responsible for degenerative changes in joints that contribute to the development of OA. Read More

Life Sci 2021 Aug 21;278:119528. Epub 2021 Apr 21.

Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 301620, China. Electronic address:

We aimed to identify RNA N6-methyladenosine methylation associated genes in osteoarthritis (OA), and to explore possible regulatory mechanisms of these RNA methylation associated genes. Bioinformatics analyses, including differential expression analysis, functional enrichment analysis, verification analysis, and box plot analysis, were conducted based on different datasets from OA and non-OA patients. Gene expression at mRNA and protein levels was determined by quantitative reverse transcription PCR, western blot and immunofluorescence. Read More