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Bone 2022 Aug 6:116513. Epub 2022 Aug 6.

Translation and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; James Cook University Hospital, Middlesbrough, UK.

Men with distal forearm fractures have reduced bone density, an increased risk of osteoporosis and of further fractures. The aim of the study was to investigate the structural determinants of these observations using quantitative CT (qCT). Ninety six men with low-trauma distal forearm fracture and 101 age-matched healthy control subjects were recruited. Read More

Pediatr Nephrol 2022 Aug 9. Epub 2022 Aug 9.

Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Reports on long-term complications of childhood-onset nephrotic syndrome (NS), such as obesity, osteoporosis, growth failure, and hypertension, are mostly from developed countries not representing South Asian ethnicities. Furthermore, data on cardiovascular health among patients with childhood-onset NS are limited.

Methods: This was an observational study involving patients attending a tertiary care center. Read More

Spine (Phila Pa 1976) 2022 Aug 9. Epub 2022 Aug 9.

Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA.

Study Design: Prospective Randomized Placebo Controlled Animal Trial.

Objective: Determine the effect of daily subcutaneous abaloparatide injection on the intervertebral fusion rate in rabbits undergoing posterolateral fusion.

Study Of Background Data: Despite the wide utilization of spine fusion, pseudarthrosis remains prevalent and results in increased morbidity. Read More

Elife 2022 Aug 9;11. Epub 2022 Aug 9.

Renal Research Institute, New York, United States.

For the treatment of postmenopausal osteoporosis, several drug classes with different mechanisms of action are available. Since only a limited set of dosing regimens and drug combinations can be tested in clinical trials, it is currently unclear whether common medication strategies achieve optimal bone mineral density gains or are outperformed by alternative dosing schemes and combination therapies that have not been explored so far. Here, we develop a mathematical framework of drug interventions for postmenopausal osteoporosis that unifies fundamental mechanisms of bone remodeling and the mechanisms of action of four drug classes: bisphosphonates, parathyroid hormone analogs, sclerostin inhibitors, and receptor activator of NF-κB ligand inhibitors. Read More

Bone Rep 2022 Dec 1;17:101609. Epub 2022 Aug 1.

Department of Biomedical Engineering, Indiana University-Purdue University at Indianapolis, Indianapolis, IN, USA.

Diabetes Mellitus is a metabolic disease which profoundly affects many organ systems in the body, including the skeleton. As is often the case with biology, there are inherent differences between the sexes when considering skeletal development and disease progression and outcome. Therefore, the aim of this study was to develop a protocol to reliably induce diabetes in both sexes of the C57BL/6 mouse utilizing streptozotocin (STZ) and to characterize the resulting bone phenotype. Read More