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Eur J Med Genet 2022 Aug 10:104591. Epub 2022 Aug 10.

Diagnostics Division, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana, 500039, India. Electronic address:

Bamforth-Lazarus syndrome is a rare autosomal recessive disease caused by biallelic loss-of-function variants in the FOXE1 gene. The condition is characterized by congenital hypothyroidism due to thyroid agenesis or thyroid hypoplasia, cleft palate, spiky hair, with or without choanal atresia, and bifid epiglottis. To date, seven pathogenic variants have been reported in the FOXE1 gene causing Bamforth-Lazarus syndrome. Read More

Toxicol Lett 2022 Aug 10. Epub 2022 Aug 10.

Laboratory of Reproductive Toxicology, Department of Medicine, State University of Centro-Oeste (UNICENTRO), Rua Simeão Camargo Varela de Sa, 03, Zip-Code 85040-080, Parana, Brazil. Electronic address:

Isoflavones are phytoestrogens with recognized estrogenic activity but may also affect testosterone, corticosterone and thyroid hormone levels in experimental models. However, the molecular mechanisms involved in these alterations are still unclear. Isoflavones are present in soy-based infant formula, in breast milk after the consumption of soy by the mother and are widely used for the preparation of beverages consumed by toddlers and teenagers. Read More

J Neurosurg 2022 Aug 12:1-11. Epub 2022 Aug 12.

Departments of2Neurosurgery.

Objective: Stereotactic radiosurgery (SRS), combined with contemporary targeted therapies and immunotherapies, has improved the overall survival of patients with lung adenocarcinoma (ADC). Given that histological subtypes reflect prognosis in patients with primary ADC, it is important to integrate pathological biomarkers to predict clinical outcomes after SRS in patients with brain metastases from lung ADC. Therefore, the authors investigated the prognostic relevance of various biomarkers of primary lung ADC for clinical outcomes after SRS. Read More

Wiad Lek 2022 ;75(6):1664-1668

BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE.

Objective: The aim: Substantiation of the need for monitoring in environmental objects of spiromesifen, spirodiclofen and spirotetramat, taking into account their specific impact on the human organism to reduce the risk of their negative influence on public health and the environment.

Patients And Methods: Materials and methods: The subject was insecticides, the class of tetramic and tetronic acids derivatives, spiromesifen, spirodiclofen and spirotetramate. Physico-chemical, toxicological and hygienic evaluation of the results was performed according to the literature data. Read More

BMC Pulm Med 2022 Aug 12;22(1):310. Epub 2022 Aug 12.

Department of Cardiothoracic Surgery, The First People's Hospital of Lianyungang, Lianyungang, People's Republic of China.

Background: High mobility group protein B2 (HMGB2) is a multifunctional protein that plays various roles in different cellular compartments. Moreover, HMGB2 serves as a potential prognostic biomarker and therapeutic target for lung adenocarcinoma (LUAD).

Methods: In this study, the expression pattern, prognostic implication, and potential role of HMGB2 in LUAD were evaluated using the integrated bioinformatics analyses based on public available mRNA expression profiles from The Cancer Genome Atlas and Gene Expression Omnibus databases, both at the single-cell level and the tissue level. Read More