Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

Management dilemma in metastatic papillary thyroid carcinoma.

Authors:
Cheerag Bharatbhai Patel Omid Ahmadi Charles de Groot James Sanders

N Z Med J 2022 Jun 10;135(1556):127-131. Epub 2022 Jun 10.

Department of Otolaryngology-Head and Neck Surgery, Waikato Hospital, New Zealand.

Papillary thyroid cancer is the most common type of well-differentiated thyroid cancer. It is associated with a survival rate greater than 95% with appropriate treatment, particularly in younger patients. We present the unique case of a 25-year-old male with severe Autistic spectrum disorder (ASD) with a right level V neck mass of several months. Due to his severe ASD, his first assessment was conducted in the hospital foyer, and every subsequent clinical assessment and blood test required a general anaesthetic (GA). He was subsequently diagnosed with T2 N1b M0 (Stage I) papillary thyroid cancer. He required extensive multidisciplinary team (MDT) input to determine the goal for his treatment whilst taking into consideration perioperative care, wound management, compliance with exam and blood tests, radioactive iodine administration and lifelong medication requirements if total thyroidectomy was considered. Following multiple MDT and family meetings, the decision was made to proceed with right hemi-thyroidectomy, right level I-V and central neck dissection. He required one-week stay in the intensive care unit under sedation post-operatively, and was discharged from hospital a further six days later with no complications. He is currently being followed-up every six months which presents its own challenges. This case highlights the extraordinary challenges and considerations that need to be made when dealing with surgical pathology in a patient with severe intellectual disability, even in the setting of a relatively common surgical pathology.

Download full-text PDF

 Source
June 2022

Publication Analysis

Top Keywords

thyroid cancer
12
papillary thyroid
12
surgical pathology
8
common surgical
4
wound management
4
management compliance
4
compliance exam
4
exam blood
4
blood tests
4
tests radioactive
4
radioactive iodine
4
iodine administration
4
administration lifelong
4
perioperative care
4
lifelong medication
4
medication requirements
4
requirements total
4
total thyroidectomy
4
thyroidectomy considered
4
considered multiple
4

Keyword Occurance

Similar Publications

CD146 interaction with integrin β1 activates LATS1-YAP signaling and induces radiation-resistance in breast cancer cells.

Authors:
Yuanke Liang Xiaoling Zhou Qin Xie Hexing Sun Kaiyuan Huang Huan Chen Wende Wang Benqing Zhou Xiaolong Wei De Zeng Haoyu Lin

Cancer Lett 2022 Aug 6:215856. Epub 2022 Aug 6.

Department of Thyroid and Breast Surgery, Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College (SUMC), 57 Changping Road, Shantou, 515000, China; Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Shantou, 515000, China. Electronic address:

Radiotherapy is an indispensable modality in comprehensive treatment of breast cancer. However, inherent or acquired radiation resistance of tumors compromises the efficacy of radiotherapy. Herein, we found that CD146, a unique epithelial-to-mesenchymal transition (EMT) inducer particularly highly expressed in triple-negative breast cancer (TNBC), is dramatically induced by ionizing irradiation. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

A deep learning-based algorithm for tall cell detection in papillary thyroid carcinoma.

Authors:
Sebastian Stenman Nina Linder Mikael Lundin Caj Haglund Johanna Arola Johan Lundin

PLoS One 2022 9;17(8):e0272696. Epub 2022 Aug 9.

Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland.

Introduction: According to the World Health Organization, the tall cell variant (TCV) is an aggressive subtype of papillary thyroid carcinoma (PTC) comprising at least 30% epithelial cells two to three times as tall as they are wide. In practice, applying this definition is difficult causing substantial interobserver variability. We aimed to train a deep learning algorithm to detect and quantify the proportion of tall cells (TCs) in PTC. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Risk factors of SARS-CoV-2 infection in cancer patients pre- and post-vaccination.

Authors:
Suliman A Alsagaby Naif Khalaf Alharbi Fahad A Alhumaydhi Faisal Alsubaie Mohammad Bosaeed Abdulrhman Aljouie Abdullah M Assiri Kanan Alshammari

PLoS One 2022 9;17(8):e0272869. Epub 2022 Aug 9.

King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.

Background: Severe complications from COVID-19 and poor responses to SARS-CoV-2 vaccination were commonly reported in cancer patients compared to those without cancer. Therefore, the identification of predisposing factors to SARS-CoV-2 infection in cancer patients would assist in the prevention of COVID-19 and improve vaccination strategies. The literature lacks reports on this topic from the Kingdom of Saudi Arabia (KSA). Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Thyroid Cancer Incidence, Clinical Presentation, and Survival Among Native Hawaiian and Other Pacific Islanders.

Authors:
Peter K Moon Tatenda Chakoma Yifei Ma Uchechukwu C Megwalu

Otolaryngol Head Neck Surg 2022 Aug 9:1945998221118538. Epub 2022 Aug 9.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Stanford University, Stanford, California, USA.

Objective: To assess the incidence, clinical presentation, and survival in Native Hawaiian and other Pacific Islander (NHPI) patients with well-differentiated thyroid cancer.

Study Design: This population-based incidence analysis and retrospective cohort study utilized data from the Surveillance, Epidemiology, and End Results database.

Setting: Incidence analysis included patients diagnosed between 1990 and 2014, while the cohort to study clinical presentation and survival comprised patients diagnosed between 2004 and 2015. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Radiofrequency ablation (RFA) compared to observation for benign thyroid nodules: emerging considerations for judicious use.

Authors:
Catherine F Sinclair Amanda J Bastien Allen S Ho

Curr Opin Endocrinol Diabetes Obes 2022 Aug 10. Epub 2022 Aug 10.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Cedars-Sinai Medical Center.

Purpose Of Review: Radiofrequency ablation (RFA) for thyroid nodules confers tangible advantages over surgery, which include promising outcomes in the context of a minimally invasive procedure and the functional benefits of organ preservation. However, the ubiquity of benign nodules worldwide may spur the risk of misuse in cases where there is negligible gain over conventional surveillance. This review summarizes new developments in RFA and examines its judicious utilization in benign nodules. Read More

View Article and Full-Text PDF
August 2022
Similar Publications
}