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Epilepsy Res 2022 Aug 7;185:106996. Epub 2022 Aug 7.

Division of Neurology and Pediatric Epilepsy Program, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA 19104, USA; Orphan Disease Center, Suite 1200, 125 S 31st St, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Departments of Pediatrics and Neurology, University of Pennsylvania Perelman School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA. Electronic address:

Purpose: Pharmaceutical grade cannabidiol (CBD) is one of the newest anti-seizure medications for refractory epilepsy, and the effects of CBD on EEG have not been fully described.

Methods: Patients enrolled in a CBD expanded access study had EEGs prior to and 12 weeks after initiation of CBD treatment for their refractory epilepsy. In addition to evaluating the clinical EEG reports, a nonbiased quantitative EEG (qEEG) analysis of background EEG was performed to determine whether consistent changes occur in the EEG in response to administration of CBD. Read More

EJNMMI Res 2022 Aug 13;12(1):49. Epub 2022 Aug 13.

Institute for Nanostructures, Nanomodelling and Nanofabrication (i3N), Department of Physics, University of Aveiro (DFis-UA), 3810-193, Aveiro, Portugal.

The experimental outcomes of small-animal positron emission tomography (PET) imaging with F-labelled fluorodeoxyglucose (F-FDG) can be particularly compromised by animal preparation and care. Several works intend to improve research reporting and amplify the quality and reliability of published research. Though these works provide valuable information to plan and conduct animal studies, manuscripts describe different methodologies-standardization does not exist. Read More

J Surg Oncol 2022 Aug 13. Epub 2022 Aug 13.

Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Backgrounds And Objectives: This investigation described clinicopathological features and outcomes of extraskeletal myxoid chondrosarcoma (EMC) patients.

Methods: EMC patients were identified from the United States Sarcoma Collaborative database between 2000 and 2016. Overall survival (OS) and recurrence-free survival (RFS) were calculated, and prognostic factors were analyzed. Read More

J Thromb Haemost 2022 Aug 13. Epub 2022 Aug 13.

University of Michigan Department of Internal Medicine, Frankel Cardiovascular Center.

Background: Differences in clinical outcomes following a temporary interruption of warfarin or a direct oral anticoagulant (DOAC) for a surgical procedure are not well described. Differences in patient characteristics from practice-based cohorts have not typically been accounted for in prior analyses.

Aim: To describe risk-adjusted differences in postoperative outcomes following an interruption of warfarin vs DOACs. Read More

Int Orthop 2022 Aug 13. Epub 2022 Aug 13.

Orthopaedics Surgery and Sports Medicine Department, FIFA Medical Center of Excellence, Croix-Rousse Hospital, Lyon University Hospital, 103 Grande rue de la Croix-Rousse, 69004, Lyon, France.

Purpose: Anterior cruciate ligament (ACL) deficiency can be a consequence or a cause of femoro-tibial osteoarthritis (OA). Several studies have published satisfactory outcomes of unicompartimental knee arthroplasty (UKA) and combined ACL reconstruction despite its absence classically being considered a contraindication. A major challenge in the ACL deficient knee is obtaining appropriate gap balancing and limb axis. Read More