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J Clin Sleep Med 2022 Aug 15. Epub 2022 Aug 15.

Department of Otolaryngology Head and Neck Surgery, Eastern Virginia Medical School Department of Pediatric Sleep Medicine, Children's Hospital of The King's Daughters, Norfolk, VA.

Study Objectives: (1) To assess adenotonsillectomy (AT) outcomes in obese adolescents with obstructive sleep apnea (OSA); (2) To identify clinical factors predicting OSA in adolescents following AT.

Methods: Obese adolescents 12 to 18 years old that underwent AT for OSA were included. Subjects had pre- and post-AT polysomnogram. Read More

Neurology 2022 Aug 11. Epub 2022 Aug 11.

Dubowitz Neuromuscular Centre, UCL Great Ormond Street Institute of Child Health & Great Ormond Street Hospital, London, UK

Background: The decline of respiratory function in Duchenne muscular dystrophy (DMD) is associated with sleep disordered breathing (SDB) and alteration of nocturnal gas exchange, first manifesting as nocturnal hypoventilation (NH). However, the correlation between pulmonary function measured by spirometry (PFT) and the onset of SDB with or without NH is unclear.

Aim: To identify the prevalence and features of SDB and to investigate the relationship between lung function determined by forced vital capacity (FVC) and sleep abnormalities in a large paediatric DMD population. Read More

J Clin Sleep Med 2022 Aug 8. Epub 2022 Aug 8.

Department of Neurology, Division of Sleep Medicine, Northwestern University.

Study Objectives: Evaluate per patient diagnostic performance of a flexible wireless dual sensor system (ANNE sleep) compared to reference standard polysomnography (PSG) for the diagnosis of moderate and severe obstructive sleep apnea (OSA) with a minimum prespecified threshold of 80% for both sensitivity and specificity.

Methods: A multicenter clinical trial was conducted to evaluate ANNE sleep versus PSG to diagnose moderate and severe OSA in individuals 22 years or older. For each testing approach apnea-hypopnea index (AHI) was manually scored and averaged by 3 registered sleep technologists blinded to the other system. Read More

Front Pediatr 2022 12;10:882352. Epub 2022 Jul 12.

Child Health Big Data Research Center, Capital Institute of Pediatrics, Beijing, China.

Background: Central apnea (CA) events always can be seen in the polysomnographic (PSG) reports of children with obstructive sleep apnea (OSA), and sometimes the central apnea index (CAI) is higher than the obstructive apnea and hypopnea index (OAHI). Commonly, the clinicians only attribute it to the age. This study aims to elucidate the distribution characteristics and major factors associated with CA in pediatric OSA. Read More

Sleep 2022 Jul 29. Epub 2022 Jul 29.

The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

Study Objectives: To identify genetic susceptibility variants in pediatric obstructive sleep apnea in European American and African American children.

Methods: A phenotyping algorithm using electronic medical records was developed to recruit cases with OSA and control subjects from the Center for Applied Genomics at Children's Hospital of Philadelphia (CHOP.) Genome-wide association studies (GWAS) were performed in pediatric OSA cases and control subjects with European American (EA) and African American (AA) ancestry followed by meta-analysis and sex stratification. Read More