Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

Poorly Differentiated Neuroendocrine Carcinoma of Unknown Primary with Metastasis to the Testis: A Case Report.

Authors:
Momoko Sano Masaaki Noguchi Akiyoshi Kinoshita Mayo Nakamura Kazuhiko Koike Masayuki Saruta

Case Rep Oncol 2022 Jan-Apr;15(1):388-393. Epub 2022 Apr 8.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Neuroendocrine neoplasms are rare epithelial neoplasms with neuroendocrine differentiation. Few cases of primary testicular poorly differentiated neuroendocrine carcinomas (PD-NECs) have been reported, and secondary testicular neoplasms are rare. A 61-year-old man with a chief complaint of left testicular swelling was referred to our hospital. An orchiectomy was performed in order to determine the pathological diagnosis. Pathological examination showed diffuse sheets of highly atypical cells that were positive for neuroendocrine markers and a Ki-67 proliferation index of 80%. The patient was diagnosed with poorly differentiated small-cell NEC. Contrast-enhanced computed tomography revealed multiple metastases to the pancreas, adrenal glands, and lymph nodes. Esophagogastroduodenoscopy showed multiple gastric metastases, and biopsy revealed the same histological findings as observed for the testicular tumor. Contrast-enhanced magnetic resonance imaging of the head also revealed multiple brain metastases. The confirmed diagnosis was PD-NEC of unknown primary with metastases to the testis, stomach, pancreas, adrenal glands, brain, and lymph nodes. We started the first-line chemotherapy with etoposide and cisplatin. Stereotactic radiotherapy for the brain metastases was administered between the first and second cycles. After five cycles, a partial response was observed; however, disease progression was observed after seven cycles with recurrence of the brain metastases and enlargement of all tumors. To our knowledge, this is the first report of an unknown primary PD-NEC with metastasis to the testis.

Download full-text PDF

 Source
http://dx.doi.org/10.1159/000523989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149520PMC
April 2022

Publication Analysis

Top Keywords

brain metastases
12
unknown primary
12
metastasis testis
8
lymph nodes
8
adrenal glands
8
pancreas adrenal
8
revealed multiple
8
differentiated neuroendocrine
8
neoplasms rare
8
metastases
6
diagnosed differentiated
4
gastric metastases
4
metastases biopsy
4
biopsy revealed
4
revealed histological
4
histological findings
4
findings observed
4
observed testicular
4
esophagogastroduodenoscopy multiple
4
testicular tumor
4

Keyword Occurance

Similar Publications

Etiology- and region-specific characteristics of transependymal cerebrospinal fluid flow.

Authors:
Peter H Yang Alison Almgren-Bell Hongjie Gu Anna V Dowling Sangami Pugazenthi Kimberly Mackey Esther B Dupépé Jennifer M Strahle

J Neurosurg Pediatr 2022 Aug 12:1-11. Epub 2022 Aug 12.

1Department of Neurological Surgery, Washington University School of Medicine, St. Louis.

Objective: Transependymal flow (TEF) of CSF, often delineated as T2-weighted hyperintensity adjacent to the lateral ventricles on MRI, is a known imaging finding, usually in the setting of CSF flow disturbances. Specific radiological features of TEF and their relationships with clinical markers of hydrocephalus and underlying disease pathology are not known. Here, the authors describe the radiological features and clinical associations of TEF with implications for CSF circulation in the setting of intracranial pathology. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Use of thyroid transcription factor 1 and napsin A to predict local failure and survival after Gamma Knife radiosurgery in patients with brain metastases from lung adenocarcinoma.

Authors:
Haewon Roh Sung Yong Lee Jinhwan Lee Soon-Young Hwang Jong Hyun Kim

J Neurosurg 2022 Aug 12:1-11. Epub 2022 Aug 12.

Departments of2Neurosurgery.

Objective: Stereotactic radiosurgery (SRS), combined with contemporary targeted therapies and immunotherapies, has improved the overall survival of patients with lung adenocarcinoma (ADC). Given that histological subtypes reflect prognosis in patients with primary ADC, it is important to integrate pathological biomarkers to predict clinical outcomes after SRS in patients with brain metastases from lung ADC. Therefore, the authors investigated the prognostic relevance of various biomarkers of primary lung ADC for clinical outcomes after SRS. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Radiation therapy for melanoma brain metastases: a systematic review.

Authors:
John F Thompson Gabrielle J Williams Angela M Hong

Radiol Oncol 2022 Aug 14;56(3):267-284. Epub 2022 Aug 14.

Melanoma Institute Australia, The University of Sydney, North Sydney, NSW, Australia.

Background: Radiation therapy (RT) for melanoma brain metastases, delivered either as whole brain radiation therapy (WBRT) or as stereotactic radiosurgery (SRS), is an established component of treatment for this condition. However, evidence allowing comparison of the outcomes, advantages and disadvantages of the two RT modalities is scant, with very few randomised controlled trials having been conducted. This has led to considerable uncertainty and inconsistent guideline recommendations. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Portal dosimetry correction method for validation of single isocenter VMAT plans for multiple brain metastases.

Authors:
Ronald J Lalonde M Saiful Huq

J Appl Clin Med Phys 2022 Aug 12:e13710. Epub 2022 Aug 12.

Department of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.

Portal dosimetry is one option for verification of volumetric-modulated arc therapy (VMAT) planning for multiple brain metastases. However, due to the changing response of the portal imager with photon beam energy, the dose transmitted through closed multileaf collimator (MLC) leaves or narrow MLC gaps may be underestimated by the imager. We present a simple method for correcting for these effects that may be implemented within the Eclipse treatment planning system. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Analysis of Rates of Brain Metastases and Association With Breast Cancer Subtypes in Ontario, Canada.

Authors:
Xin Ye Wang Michael N Rosen Rania Chehade Arjun Sahgal Sunit Das Ellen Warner Refik Saskin Bo Zhang Hany Soliman Kelvin K W Chan Katarzyna J Jerzak

JAMA Netw Open 2022 Aug 1;5(8):e2225424. Epub 2022 Aug 1.

Institute of Medical Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Importance: Approximately 1 in 7 patients with metastatic breast cancer (MBC) will receive radiotherapy for brain metastases (BRM). Significant differences in cumulative incidence of BRM by breast cancer subtype may inform future BRM screening protocols.

Objective: To describe cumulative incidence of BRM among patients with de novo MBC. Read More

View Article and Full-Text PDF
August 2022
Similar Publications
}