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Aging (Albany NY) 2022 Aug 13;14(undefined). Epub 2022 Aug 13.

Department of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang 110001, Liaoning, P.R. China.

Serum amyloid A-like 1 (SAAL1) was recently identified as a novel oncogene in hepatocellular carcinoma (HCC). To explore the potential role of SAAL1 in other cancers, we conducted a pan-cancer analysis of SAAL1 expression and its association with tumor microenvironment (TME) immunological profiles, sensitivity to chemotherapy agents, response to immunotherapy, and patient prognosis. SAAL1 was overexpressed in most malignant tumors in association with poor prognosis. Read More

World Neurosurg 2022 Aug 10. Epub 2022 Aug 10.

Department of Orthopaedic Surgery, Rothman Orthopaedic Institute, Thomas Jefferson University, Philadelphia, PA 19107.

Objectives: To 1) compare the rates of different fusion techniques using a nationwide database over the last decade and 2) identify differences in complications and readmissions based on fusion technique.

Methods: All elective, single-level lumbar fusions performed by orthopaedic surgeons from 2011-2020 were identified from the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP). Rates of lumbar fusion technique (posterolateral fusion (PLDF), transforaminal lumbar interbody fusion + PLDF (TLIF), anterior lumbar interbody fusion (ALIF/LLIF), and anterior lumbar interbody fusion + PLDF (ALIF/LLIF+PLDF) were recorded. Read More

Neurologia (Engl Ed) 2022 Aug 10. Epub 2022 Aug 10.

Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: The prevalence of sexual dysfunction (SD) in men with multiple sclerosis (MS) is reported variously in different studies. The most common form of SD in these patients is erectile dysfunction (ED). The goal of this systematic review and meta- analysis is to determine the pooled prevalence of SD and ED in men suffering from MS. Read More

Neurologia (Engl Ed) 2022 Aug 10. Epub 2022 Aug 10.

Laboratory of Neurobiology, Institute of Neurosciences, IdISSC, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain; Department of Neurology, Institute of Neurosciences, IdISSC, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain.

Introduction: Genomic studies have identified numerous genetic variants associated with susceptibility to multiple sclerosis (MS); however, each one explains only a small percentage of the risk of developing the disease. These variants are located in genes involved in specific pathways, which supports the hypothesis that the risk of developing MS may be linked to alterations in these pathways, rather than in specific genes. We analyzed the role of the TNFRSF1A gene, which encodes one of the TNF-α receptors involved in a signaling pathway previously linked to autoimmune disease. Read More

Photodiagnosis Photodyn Ther 2022 Aug 10:103063. Epub 2022 Aug 10.

Thoracic Surgery Department, Taoyuan General Hospital, Ministry of Health and Welfare, No. 1492, Zhongshan Rd. Taoyuan Dist., Taoyuan City, Taiwan (R.O.C) 33004. Electronic address:

Background: Photodynamic therapy involves using a tumor-specific photosensitizer and laser illumination and is recommended for treating early, centrally located lung cancers, but it is not a standard treatment for peripheral lung tumor until now. We previously proposed a novel light delivery method, in which lipiodol is perfused into the bronchial tree to increase the scope of illumination via the fiber effect. Herein, we attempted this novel technique under electromagnetic bronchoscope guidance in a hybrid operation room where lipiodol facilitated light diffusion, and evaluated the effectiveness and feasibility of this technique for peripheral lung cancers. Read More