Search Our Scientific Publications & Authors

J Shoulder Elbow Surg 2022 Aug 2. Epub 2022 Aug 2.

Department of Orthopaedics and Sports Medicine, University of Washington; the Orthopedics Section S-112-ORT, VA Puget Sound Health Care System, 1959 NE Pacific Street, Box 356500, Seattle, WA 98195, USA. Electronic address:

Repetitive stress injuries to the human shoulder rotator cuff, and particularly the supraspinatus tendon (SST), are highly prevalent and debilitating. These injuries typically occur through application of cyclic load below the threshold necessary to cause acute tears, leading to accumulation of incremental damage that exceeds the body's ability to heal, resulting in decreased mechanical strength and increased risk of frank rupture at lower loads. Consistent progression of fatigue damage across multiple model systems suggests a generalized tendon response to overuse. Read More

J Am Heart Assoc 2022 Aug 5;11(16):e025232. Epub 2022 Aug 5.

Department of Molecular Innovation in Lipidology National Cerebral & Cardiovascular Center Research Institute Suita Osaka.

Background Heterozygous familial hypercholesterolemia (HeFH) more likely exhibits extensive atherosclerotic disease at multiple vascular beds. Lipoprotein(a) (Lp(a)) is an atherogenic lipoprotein that elevates HeFH-related atherosclerotic cardiovascular disease risks. Whether circulating Lp(a) level associates with polyvascular propagation of atherosclerosis in subjects with HeFH remains uncertain. Read More

In Vitro Cell Dev Biol Anim 2022 Aug 4. Epub 2022 Aug 4.

Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark.

JBJS Rev 2022 Jul 4;10(7). Epub 2022 Aug 4.

Paris Shoulder Unit, Clinique Bizet, Paris, France.

»: Anterior glenohumeral instability (AGI) is a challenging condition that requires close attention to osseous and soft-tissue abnormalities. The morphometric variance of the periarticular scapular anatomy may be involved in the pathogenesis of recurrent traumatic anterior instability.

»: The Trillat procedure repositions the coracoid medially and downward by a partial wedge osteotomy, mimicking the sling effect of the Latarjet procedure by moving the conjoint tendon closer to the joint line in throwing position. Read More

Stem Cell Res Ther 2022 Jul 29;13(1):380. Epub 2022 Jul 29.

Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong, SAR, China.

Background: Tendon healing is clinically challenging largely due to its inferior regenerative capacity. We have previously prepared a soluble, DNA-free, urea-extracted bovine tendon-derived extracellular matrix (tECM) that exhibits strong pro-tenogenic bioactivity on human adipose-derived stem cells (hASCs). In this study, we aimed to elucidate the mechanism of tECM bioactivity via characterization of tECM protein composition and comparison of transcriptomic profiles of hASC cultures treated with tECM versus collagen type I (Col1) as a control ECM component. Read More