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Delayed Onset Heparin-Induced Thrombocytopenia Presenting as Fever of Unknown Origin.

Authors:
Abhinav Karan Hui Jun Guo Fadi Kandah Pramod Reddy

Am J Med 2022 Jun 6. Epub 2022 Jun 6.

Department of Internal Medicine, University of Florida College of Medicine, Jacksonville.

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http://dx.doi.org/10.1016/j.amjmed.2022.05.019DOI Listing
June 2022

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Mesalamine and cholestyramine for immune checkpoint inhibitor-mediated diarrhea and colitis.

Authors:
Barbara Hollander Shruti Khurana Jake S Jacob Melmet Altan Jianbo Wang Dan Zhao Krishnavathana Varatharajalu Mazen Alasadi Anusha S Thomas Yinghong Wang

J Cancer Res Clin Oncol 2022 Aug 16. Epub 2022 Aug 16.

Department of Gastroenterology, Hepatology and Nutrition, Unit 1466, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

Purpose: Immune checkpoint inhibitors (ICI) are effective against various malignancies. However, adverse events including diarrhea and colitis can lead to significant morbidity and mortality. Recommendations for the management of ICI mediated diarrhea and colitis include steroids and biologics. Read More

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August 2022
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Early versus delayed enteral nutrition for neonatal hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia: a randomized controlled trial.

Authors:
Ya Hu Feng Chen Xinyu Xiang Fang Wang Ziyu Hua Hong Wei

Ital J Pediatr 2022 Aug 15;48(1):146. Epub 2022 Aug 15.

Department of Neonatology, Children's Hospital of Chongqing Medical University (The institution is also validated by Ringgold as 'Chongqing Medical University Affiliated Children's Hospital'), Chongqing, China.

Background: The practice of therapeutic hypothermia (TH) is widely used for neonatal hypoxic-ischemic encephalopathy (HIE) despite its corresponding feeding strategies are still controversial. This randomized controlled trial (RCT) demonstrated to evaluate the effect of early vs. delayed enteral nutrition on the incidence of feeding intolerance (FI) and other association during TH. Read More

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August 2022
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[Sleepiness among adolescents: etiology and multiple consequences].

Authors:
W Davidson-Urbain S Servot R Godbout J-Y Montplaisir E Touchette

Encephale 2022 Aug 12. Epub 2022 Aug 12.

Département de psychoéducation, université du Québec à Trois-Rivières, Québec, Canada; Centre de recherche universitaire sur les jeunes et les familles, Québec, Canada; Centre d'études avancées en médecine du sommeil, hôpital du Sacré-Cœur, Québec, Canada; Centre intégré universitaire de santé et de services sociaux du Nord-de-l'île-de-Montréal, Québec, Canada; Groupe de recherche en inadaptation psychosociale, Québec, Canada. Electronic address:

Over the past century a dramatic decline in sleep duration among adolescents, such as more than one hour of sleep loss per night, has been reported. A debt in sleep duration could lead to sleep deprivation, a major risk factor associated with daytime sleepiness. Sleepiness refers to the inability to maintain an adequate level of alertness during the day which may result in more or less being able to control falling asleep at inappropriate times. Read More

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August 2022
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Effects of sensory nerve blockade on cutaneous microvascular responses to ischemia-reperfusion injury.

Authors:
Gregory W McGarr Stephen S Cheung

Microvasc Res 2022 Aug 12:104422. Epub 2022 Aug 12.

Environmental Ergonomics Laboratory, Department of Kinesiology, Brock University, St. Catharines, ON, Canada. Electronic address:

Objective: Examine the effects of sensory nerve blockade on cutaneous post-occlusive reactive hyperemia (PORH) and local thermal hyperemia (LTH) following prolonged upper limb ischemia.

Materials And Methods: In nine males [28 years (standard deviation:6)], volar forearm skin blood flux normalized to maximum vasodilation (%SkBF) was assessed at control (CTRL) and sensory nerve blockade (EMLA) treated sites during the PORH response following 20-min of complete arm ischemia and during rapid LTH (33-42 °C, 1 °C·20 s, held for ~30-min + 20-min at 44 °C) before and after ischemia-reperfusion (IR) injury.

Results: EMLA increased mean [95 % confidence-interval] PORH amplitude by 21%SkBF ([9,33]; p = 0. Read More

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August 2022
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Relationship Between Intraoperative Electrocochleography Responses and Immediate Postoperative Bone Conduction Thresholds in Cochlear Implantation.

Authors:
Aniket A Saoji Madison K Graham Weston J Adkins Ashley M Nassiri Brian A Neff Matthew L Carlson Colin L W Driscoll

Otol Neurotol 2022 Sep;43(8):e880-e887

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic School of Medicine, Rochester, Minnesotta.

Objective: To determine the relationship between intraoperative electrocochleography (ECochG) measurements and residual hearing preservation after cochlear implant (CI) surgery by comparing differences between preoperative and immediate postoperative bone conduction thresholds.

Study Design: Prospective cohort study.

Setting: Tertiary academic referral center. Read More

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September 2022
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