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Chemosphere 2022 Aug 9:135930. Epub 2022 Aug 9.

Institute of Environmental Sciences (CML), Leiden University, PO Box 9518, 2300 RA, Leiden, the Netherlands.

Engineered nanomaterials (ENMs) are ubiquitous nowadays, finding their application in different fields of technology and various consumer products. Virtually any chemical can be manipulated at the nano-scale to display unique characteristics which makes them appealing over larger sized materials. As the production and development of ENMs have increased considerably over time, so too have concerns regarding their adverse effects and environmental impacts. Read More

Anal Biochem 2022 Aug 9:114838. Epub 2022 Aug 9.

Department of Pharmaceutical and Biological Engineering, School of Chemical Engineering, Sichuan University, Chengdu, 610065, China. Electronic address:

Tyrosinase plays a vital role for melanogenesis and inherently involves both monophenolase activity and diphenolase activity. Monophenolase catalyzes hydroxylation of tyrosine to l-DOPA (L-3,4-dihydroxyphenylalanine). Real-time monophenolase assay method is of outstanding interest for both scientific research and industrial application. Read More

Comput Biol Med 2022 Aug 7;148:105914. Epub 2022 Aug 7.

Department of Convergence Medicine, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Landmark detection in flatfoot radiographs is crucial in analyzing foot deformity. Here, we evaluated the accuracy and efficiency of the automated identification of flatfoot landmarks using a newly developed cascade convolutional neural network (CNN) algorithm, Flatfoot Landmarks AnnoTating Network (FlatNet). A total of 1200 consecutive weight-bearing lateral radiographs of the foot were acquired. Read More

Comput Methods Programs Biomed 2022 Aug 4;225:107058. Epub 2022 Aug 4.

KITE Research Institute - Toronto Rehabilitation Institute, University Health Network, 550 University Avenue, Toronto, ON M5G 2A2, Canada; Rehabilitation Sciences Institute, Temerty Faculty of Medicine, University of Toronto, ON, Canada. Electronic address:

Background And Objective: The videofluoroscopic swallowing study (VFSS) is a gold-standard imaging technique for assessing swallowing, but analysis and rating of VFSS recordings is time consuming and requires specialized training and expertise. Researchers have recently demonstrated that it is possible to automatically detect the pharyngeal phase of swallowing and to localize the bolus in VFSS recordings via computer vision approaches, fostering the development of novel techniques for automatic VFSS analysis. However, training of algorithms to perform these tasks requires large amounts of annotated data that are seldom available. Read More

PLoS Comput Biol 2022 Aug 12;18(8):e1010353. Epub 2022 Aug 12.

Department of Physics, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.

Simulations of neural activity at different levels of detail are ubiquitous in modern neurosciences, aiding the interpretation of experimental data and underlying neural mechanisms at the level of cells and circuits. Extracellular measurements of brain signals reflecting transmembrane currents throughout the neural tissue remain commonplace. The lower frequencies (≲ 300Hz) of measured signals generally stem from synaptic activity driven by recurrent interactions among neural populations and computational models should also incorporate accurate predictions of such signals. Read More