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Clin Pharmacol Ther 2022 Jun 29. Epub 2022 Jun 29.

Department of Physiology and Pharmacology, Biomedicum B5, Karolinska Institutet, Stockholm, Sweden.

During pharmacotherapy knowledge about the actual drug and metabolite concentrations in plasma is often critical. Individual dose adjustments can be done based on pre-emptive genotyping of certain ADME genes but also using therapeutic drug monitoring (TDM). Analyses of liquid biopsies for tumor derived components is now well established and found to be a good complement to biopsy examinations. Read More

PLoS One 2022 24;17(6):e0269651. Epub 2022 Jun 24.

School of Computer and Information Technology, Beijing Jiaotong University, Beijing, China.

Item co-occurrence is an important pattern in recommendation. Due to the difference in correlation, the matching degrees between the target and historical items vary. The higher the matching degree, the greater probability they co-occur. Read More

Soc Sci Med 2022 Jun 9;306:115123. Epub 2022 Jun 9.

Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland; Department of Social and Behavioural Sciences, Harvard School of Public Health, Boston, MA, USA.

Studies in Western countries suggest that receiving informal care from family members may reduce utilisation of health care services. This hypothesis has not been examined in China, where the population is ageing rapidly. We assess the impact of informal care from offspring (children and grandchildren) on health care utilisation and expenditures among older people in China. Read More

Early Hum Dev 2022 Jul 11;170:105604. Epub 2022 Jun 11.

Division of Perinatal Medicine, Policlinic Abano Terme, Abano Terme, Italy.

Objective: The aim of this study was to examine the association between prenatal stressful life events in pregnancy and breastfeeding initiation, exclusivity, and duration, defined according to the WHO.

Study Design: Feeding practices were prospectively collected from 425 puerperae living in an industrialized area of Northeast Italy starting on the second day post-partum, when they filled out the Life Experience Survey (LES, 1978).

Results: In this sample, analysis revealed that at discharge 65/358 (18. Read More

Front Cardiovasc Med 2022 9;9:848589. Epub 2022 May 9.

Facultad de Medicina, Universidad de La Frontera, Temuco, Chile.

The 2-Minute Step Test (2MST) has been presented as an alternative to the 6-Minute Walk Test (6MWT) based on the association between the two tests in older adults; however, some authors propose that it should not be a substitute but rather a complement to the latter in the fitness evaluation. Specifically, in coronary disease, despite the potential and clinical utility of 2MST, the relationship of both tests in this population is unknown. This study aimed to determine the relationship between 6MWT and 2MST and to explore the relationship of biodemographic factors for both tests in subjects with treated coronary artery disease. Read More