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J Adv Res 2022 Jul 18;39:319-332. Epub 2021 Oct 18.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Changsha, Hunan, China. Electronic address:

Introduction: Pharmacokinetic variability in disease state is common in clinical practice, but its underlying mechanism remains unclear. Recently, gut microbiota has been considered to be pharmacokinetically equivalent to the host liver. Although some studies have explored the roles of gut microbiota and host Cyp450s in drug pharmacokinetics, few have explored their effects on pharmacokinetic variability, especially in disease states. Read More

BMJ Open 2022 Jul 1;12(7):e060473. Epub 2022 Jul 1.

Centre of Health Services Research in Medicine, Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Introduction: People with mild cognitive impairment (MCI) are at increased risk of decreasing cognitive functioning. Computerised cognitive training (CCT) and nutrition have been shown to improve the cognitive capacities of people with MCI. For each variable, we developed two kinds of interventions specialised for people with MCI (CCT: 'individualised' CCT; nutrition: a whole-food, plant-based diet). Read More

BMJ Open 2022 Jul 1;12(7):e059173. Epub 2022 Jul 1.

Emergency Department, Universitair Ziekenhuis Antwerpen, Edegem, Belgium.

Objectives: In the TRIAGE trial, a cluster randomised trial about diverting emergency department (ED) patients to a general practice cooperative (GPC) using a new extension to the Manchester Triage System, the difference in the proportion of patients assigned to the GPC was striking: 13.3% in the intervention group (patients were encouraged to comply to an ED or GPC assignment, real-world setting) and 24.7% in the control group (the assignment was not communicated, all remained at the ED, simulated setting). Read More

J Rheumatol 2022 Jul 1. Epub 2022 Jul 1.

School of Medicine, Chung Shan Medical University; Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital; Institute of Medicine, Chung Shan Medical University; Graduate Institute of Integrated Medicine, China Medical University; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan. P.Y. Liao and J.K. Yang contributed equally. The authors declare no conflicts of interest relevant to this work. Address correspondence to Dr. J.C.C. Wei, Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Graduate Institute of Integrated Medicine, China Medical University; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jianguo N. Rd., Taichung City 40201, Taiwan. Email:

We have read with great interest the recent study by Meer et al on novel methods to identify risk factors for psoriatic arthritis (PsA), psoriasis, rheumatoid arthritis (RA), and ankylosing spondylitis. In that article, we appreciate that age, sex, BMI (calculated as weight in kilograms divided by height in meters squared), and time observed between the experimental group and control group were highly matched. However, we have a few suggestions to strengthen the conclusions in the study of Meer et al. Read More

Eur Respir J 2022 Jul 1. Epub 2022 Jul 1.

Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia.

Introduction: Asthma exacerbations in pregnancy are associated with adverse perinatal outcomes. We aimed to determine whether fractional exhaled nitric oxide (FENO)-based asthma management improves perinatal outcomes compared to usual care.

Methods: The Breathing for Life Trial was a multi-center, parallel group, randomised controlled trial conducted in six hospital antenatal clinics, which compared asthma management guided by fractional exhaled nitric oxide (adjustment of asthma treatment according to exhaled nitric oxide and symptoms each 6-12 weeks) to usual care (no treatment adjustment as part of the trial). Read More