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eNeuro 2022 May-Jun;9(3). Epub 2022 Jun 8.

Neural Coding and Brain Computing Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan.

Inhibitory neurons take on many forms and functions. How this diversity contributes to memory function is not completely known. Previous formal studies indicate inhibition differentiated by local and global connectivity in associative memory networks functions to rescale the level of retrieval of excitatory assemblies. Read More

Rev Neurosci 2022 Apr 22. Epub 2022 Apr 22.

Hull York Medical School, Heslington, York, YO10 5DD, UK.

There is evidence that olfactory cortex responds to its afferent input with the generation of cell assemblies: collections of principal neurons that fire together over a time scale of tens of ms. If such assemblies form an odor representation, then a fundamental question is how each assembly then induces neuronal activity in downstream structures. We have addressed this question in a detailed model of superficial layers of lateral entorhinal cortex, a recipient of input from olfactory cortex and olfactory bulb. Read More

J Physiol 2022 04 17;600(8):1991-2011. Epub 2022 Mar 17.

Institute for Physiology I, Medical Faculty, Albert-Ludwigs-University Freiburg, Freiburg, Germany.

Nasal breathing affects cognitive functions, but it has remained largely unclear how respiration-driven inputs shape information processing in neuronal circuits. Current theories emphasize the role of neuronal assemblies, coalitions of transiently active pyramidal cells, as the core unit of cortical network computations. Here, we show that the phase of respiration-related oscillations (RROs) influences the likelihood of activation of a subset of neuronal assemblies in the medial prefrontal cortex of awake mice. Read More

Phys Rev E 2022 Jan;105(1-1):014311

The Institute of Mathematical Sciences, CIT Campus, Taramani, Chennai 600113, India.

The spontaneous generation of electrical activity underpins a number of essential physiological processes, and is observed even in tissues where specialized pacemaker cells have not been identified. The emergence of periodic oscillations in diffusively coupled assemblies of excitable and electrically passive cells (which are individually incapable of sustaining autonomous activity) has been suggested as a possible mechanism underlying such phenomena. In this paper we investigate the dynamics of such assemblies in more detail by considering simple motifs of coupled electrically active and passive cells. Read More

J Phys Chem B 2022 03 16;126(8):1734-1741. Epub 2022 Feb 16.

Physical Chemistry I - Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.

The SynGAP/PSD-95 binary protein system serves as a simple mimicry of postsynaptic densities (PSDs), which are protein assemblies based largely on liquid-liquid phase separation (LLPS), that are located underneath the plasma membrane of excitatory synapses. Surprisingly, the LLPS of the SynGAP/PSD-95 system is much more pressure sensitive than typical folded states of proteins or nucleic acids. It was found that phase-separated SynGAP/PSD-95 droplets dissolve into a homogeneous solution at a pressure of tens to hundred bar. Read More