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Acta Biomater 2022 Jun 25. Epub 2022 Jun 25.

Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, Shandong, China; Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory, Jinan, Shandong, China; Shandong Engineering & Technology Research Center for Tumor Marker Detection, Jinan, Shandong, China. Electronic address:

piR-31143 has been identified as a potential biomarker for the diagnosis of colorectal cancer (CRC). However, the current detection methods have complicated operations and high cost, which restrict its clinical application. In the present work, we reported a new photoelectrochemical (PEC) biosensor based on [email protected]/TiC hybrid and duplex-specific nuclease (DSN) assisted signal amplification mechanism for ultrasensitive detection of piRNA-31143 from human serum. Read More

Gene 2022 Jun 25:146697. Epub 2022 Jun 25.

Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig 44511, Egypt.

Nicotine is one of several physiologically stable and active chemicals found in tobacco. The mechanism through which nicotine causes kidney damage is still obscure. As a result, the goal of this research was to investigate how oral nicotine intake can lead to kidney damage. Read More

Virol Sin 2022 Jun 25. Epub 2022 Jun 25.

Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. Electronic address:

Human adenoviruses type 26 (HAdV26) and type 35 (HAdV35) have increasingly become the choice of adenovirus vectors for vaccine application. However, the population pre-existing immunity to these two adenoviruses in China, which may reduce vaccine efficacy, remains largely unknown. Here, we established micro-neutralizing (MN) assays to investigate the seroprevalence of neutralizing antibodies (nAbs) against HAdV26 and HAdV35 in the general population of Guangdong and Shandong provinces, China. Read More

Asian Pac J Cancer Prev 2022 Jun 1;23(6):2071-2077. Epub 2022 Jun 1.

Department Pharmacology and Toxicology, College of Pharmacy, AL-Nahrain University, Iraq.

Objective: Angiogenesis plays a key role in tumor growth, invasion, and metastasis of cancer diseases, and therefore, the inhibition of angiogenesis can provide an important therapeutic approach in cancer diseases. The aim of this study was to investigate the inhibitory effects of methyl hydroxychalcone on ex vivo sprouting of rat aortic micro-vessels and in vivo formation of chorionic plexus in chick chorioallantoic membrane and to investigate the mechanism underlying anti-angiogenic activity.

Methods: Rat aortic rings were sectioned by 1 mm. Read More

Drug Deliv Transl Res 2022 Jun 28. Epub 2022 Jun 28.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 North Pine Street, Baltimore, MD, 21201, USA.

Due to high variability during clinical pharmacokinetic (PK) evaluation, the prediction of in vivo exposure from in vitro absorption testing of topical semisolid and liquid dermal products has historically proven difficult. Since absorption from unoccluded formulations can be influenced by environmental factors such as temperature and humidity, maximal effort must be placed on the harmonization of experimental parameters between in vitro and in vivo testing conditions to establish accurate in vitro/in vivo correlations (IVIVC). Using four different sunscreen formulations as a model, we performed in vitro permeation testing (IVPT) studies with excised human skin and maintained strict harmonization techniques to control application time, occlusion, temperature, and humidity during in vivo human serum PK evaluation. Read More