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Thorax 2022 Jul 1. Epub 2022 Jul 1.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA

Background: Interstitial lung abnormalities (ILAs) are associated with increased mortality. It is unclear whether multimorbidity accounts for the mortality association or how strongly ILA is associated with mortality relative to other common age-associated diseases. We determined the association of ILA with all-cause mortality adjusted for multimorbidity, compared mortality associated with ILA and prevalent cardiovascular disease (CVD), diabetes mellitus, chronic kidney disease, chronic obstructive pulmonary disease and cancer and also determined the association between ILA and these diseases. Read More

Ann Clin Lab Sci 2022 May;52(3):462-469

Department of Respiratory Medicine, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China

Objective: Long non-coding RNA ubiquitin-conjugating enzyme E2R2 antisense RNA 1 (UBE2R2-AS1) has been identified to be associated with cervical cancer and glioma. Nevertheless, the expression, prognostic value, and function role of UBE2R2-AS1 remain unclear in non-small cell lung cancer (NSCLC).

Methods: Fifty-nine pairs of tumor tissues and adjacent normal tissues were collected from NSCLC patients, and UBE2R2-AS1 expression was determined using quantitative real time PCR analysis. Read More

Ann Clin Lab Sci 2022 May;52(3):439-451

Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College and The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.

Objective: Cancer stem-like cells (CSLCs) are closely associated with tumor recurrence, metastasis, and drug-resistance. is related to tumorigenesis and development of non-small cell lung cancer (NSCLC). The role and regulatory mechanism of in CSLCs of NSCLC remain unclear. Read More

Eur Respir J 2022 Jul 1. Epub 2022 Jul 1.

Institute of Health Sciences, University of Leeds, UK

Question: Screening with low dose computed tomography (LDCT) reduces lung-cancer mortality; however, the most effective strategy for optimising participation is unknown. Here we present data from the Yorkshire Lung Screening Trial, including response to invitation, screening eligibility and uptake of community-based LDCT screening.

Methods: Individuals aged 55 to 80, identified from primary care records as having ever smoked, were randomised prior to consent to invitation to telephone lung cancer risk assessment or usual care. Read More

Ann Oncol 2022 Jun 28. Epub 2022 Jun 28.

Department of Pulmonary Diseases, Maastricht University Medical Centre(+), GROW School for Oncology and Reproduction, Maastricht, the Netherlands.

The standard of care for patients with stage III non-small cell lung cancer (NSCLC) is concurrent chemoradiotherapy (CCRT) followed by one year of adjuvant durvalumab. Despite the survival benefit granted by immunotherapy in this setting, only 1/3 of patients is alive and disease free at 5 years. Novel treatment strategies are under development to improve patient outcomes in this setting: different anti-programmed death-(ligand) 1 (PD-(L)1) antibodies after CCRT, consolidation immunotherapy after sequential chemoradiotherapy (SCRT), induction immunotherapy before CCRT and immunotherapy concurrent with CCRT and/or SCRT. Read More