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J Adv Res 2022 Jul 2;39:1-13. Epub 2021 Nov 2.

Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu National Agricultural Science and Technology Center, Chengdu 610000, China; Zhengzhou Research Base, State Key Laboratory of Cotton Biology, School of Agricultural Science of Zhengzhou University, Zhengzhou 450000, China; Hainan Yazhou Bay Seed Laboratory, Sanya 572025, China. Electronic address:

Introduction: Biofungicides with low toxicity and high efficiency are a global priority for sustainable agricultural development. Phytohormone salicylic acid (SA) is an ancient medicine against various diseases in humans and activates the immune system in plants, but little is known of its function as a biofungicide.

Objectives: Here, Fusarium oxysporum, the causal agent of devastating Fusarium wilt and immunodepressed patients, was used as a model system to explore whether SA can enter the pathogen cells and suppress key targets of the pathogen. Read More

J Rheumatol 2022 Jul 1. Epub 2022 Jul 1.

Division of Rheumatology, University of California, San Francisco, CA, USA; Department of Pediatrics, University of California, San Francisco, CA, USA; Division of Infectious Diseases, University of California, San Francisco, CA, USA; Department of Veterans Affairs Medical Center, San Francisco, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. Conflict of interest statement: The authors declare that no conflict of interest exists. Acknowledgements: This work is supported by NIH/NIAMS R01 AR069616, NIH/NHLBI K23HL138461-01A1, and the Rheumatology Research Foundation. Corresponding Author: Sarah Patterson, M.D. Division of Rheumatology, University of California, San Francisco Box 0500, San Francisco, CA 94122 Email:

Objective: While general population studies have shown inverse associations between physical activity and common inflammatory biomarkers, the effects of physical activity on inflammatory gene expression and signaling pathways in rheumatoid arthritis (RA) remain unknown. We aimed to determine whether physical activity independently associates with expression of inflammatory genes among people with RA.

Methods: This was a prospective observational study of adults with RA. Read More

Ann Clin Lab Sci 2022 May;52(3):426-438

Department of Head and Neck Surgery, Wuzhou Red Cross Hospital, Wuzhou, Guangxi, China.

Objective: The purpose of this study was to explore the function and mechanism of LncRNA CERS6-AS1 on papillary thyroid cancer.

Materials: CERS6-AS1, miR-497-5p, and LASP1 expression in papillary thyroid cancer tissues and cells were detected by RT-PCR. The relationship between CERS6-AS1 expression and clinical characteristics was analyzed, and overall survival was evaluated via Kaplan-Meier analysis. Read More

Ann Clin Lab Sci 2022 May;52(3):359-366

Department of Oncology, Lishui City People's Hospital (the Sixth Affiliated Hospital of Wenzhou Medical University), Lishui, Zhejiang Province, China

Objective: Pleomorphic adenoma gene like-2 (PLAGL2) belongs to PLAG protein family and functions as a zinc finger transcriptional factor to participate in the cellular processes, including cell transformation, migration, and apoptosis. Increasing evidence has shown the oncogenic role of PLAGL2 in various cancers, while the potential molecular mechanism and biology roles of PLAGL2 in diffuse large B-cell lymphoma (DLBCL) are still unclear.

Methods: Expression of PLAGL2 was found to be elevated in DLBCL cells. Read More

Ann Clin Lab Sci 2022 May;52(3):399-405

Department of Gynecology, Shunde Hospital of Southern Medical University, Foshan, Guangdong, China.

Objective: MicroRNA-186 (miR-186) and circular RNA (circRNA) circSEPT9 are two crucial players in cancer biology, while their roles in endometrial cancer (EC) are unclear. Our preliminary sequencing analysis revealed the potential crosstalk between circSEPT9 and miR-186 in EC.

Materials And Methods: The expression levels of circSEPT9 and miR-186 in EC and paired non-tumor tissues from 64 EC patients were detected by RT-qPCRs. Read More