Heart Rhythm 2022 May 10. Epub 2022 May 10.
Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Denmark; Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Denmark. Electronic address:
Clin Pharmacol Ther 2022 May 22. Epub 2022 May 22.
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Chloroquine and azithromycin were developed in combination for the preventive treatment of malaria in pregnancy, and more recently were proposed as COVID-19 treatment options. Billions of doses of chloroquine have been administered worldwide over the past 70 years but concerns regarding cardiotoxicity, notably the risk of torsades de pointes (TdP), remain. This investigation aimed to characterize the pharmacokinetics and electrocardiographic effects of chloroquine and azithromycin observed in a large previously conducted healthy volunteer study. Read More
Sci Rep 2022 May 20;12(1):8530. Epub 2022 May 20.
Department of Information Engineering, University of Pisa, Pisa, Italy.
In this work, we reported a computational study to quantitatively determine the individual contributions of three candidate arrhythmic factors associated with Brugada Syndrome. In particular, we focused our analysis on the role of structural abnormalities, dispersion of repolarization, and size of the diseased region. We developed a human phenomenological model capable of replicating the action potential characteristics both in Brugada Syndrome and in healthy conditions. Read More
Pediatr Cardiol 2022 May 18. Epub 2022 May 18.
Department of Cardiology, SickKids Hospital, 555 University Ave, Toronto, ON, M5G 1X8, Canada.
Adult studies have shown that depolarization and repolarization abnormalities are associated with worsening heart failure; however, this relationship is not well understood in pediatric congenital heart disease. We evaluated the association between QTc and QRS duration to systolic function and outcome in children with heart failure and reduced ejection fraction (HFrEF). We performed a retrospective, single-center, 14-year cohort study of HFrEF children. Read More
CPT Pharmacometrics Syst Pharmacol 2022 May 17;11(5):653-664. Epub 2022 May 17.
Department of IT Convergence Engineering, Kumoh National Institute of Technology, Gumi, Korea.
Comprehensive in vitro Proarrhythmia Assay (CiPA) projects for assessing proarrhythmic drugs suggested a logistic regression model using qNet as the Torsades de Pointes (TdP) risk assessment biomarker, obtained from in silico simulation. However, using a single in silico feature, such as qNet, cannot reflect whole characteristics related to TdP in the entire action potential (AP) shape. Thus, this study proposed a deep convolutional neural network (CNN) model using differential action potential shapes to classify three proarrhythmic risk levels: high, intermediate, and low, considering both characteristics related to TdP not only in the depolarization phase but also the repolarization phase of AP shape. Read More
Cardiol Rev 2022 May 16. Epub 2022 May 16.
Departments of Medicine and Cardiology, New York Medical College/ Westchester Medical Center, Valhalla, NY.
Congenital Long QT Syndrome (CLQTS) is the most common inherited arrhythmia. The QT interval, which marks the duration of ventricular depolarization and repolarization in the myocardium, can be prolonged due to mutations in genes coding for the ion channel proteins that govern the cardiac action potential. The lengthening of the QT interval can lead to a wide range of clinical symptoms, including seizures, torsades de pointes, and fatal arrhythmias. Read More