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Brain Inj 2022 Aug 15:1-6. Epub 2022 Aug 15.

Department of Psychology, Chuo University, Tokyo, Japan.

Objectives: Hyper- and hyposensitivity in multiple modalities have been well-documented in subjects with autistic spectrum disorder (ASD) but not in subjects with acquired brain injury (ABI). The purpose of this study was to determine whether subjects with ABI experience altered sensory processing in multiple sensory modalities, and to examine the relationships between impaired sensory processing and the emotional state.

Methods And Procedures: Sixty-eight patients with brain or spinal cord tumors participated in the study. Read More

J Pain 2022 Aug 5. Epub 2022 Aug 5.

Department of Medical Sciences, Graduate School; Department of Physiology, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon, 35015, Korea; Laboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea. Electronic address:

MAO-B inhibitors have been implicated to reverse neuropathic pain behaviors. Our previous study has demonstrated that KDS2010 (KDS), a newly developed reversible MAO-B inhibitor, could attenuate Paclitaxel (PTX)-induced tactile hypersensitivity in mice through suppressing reactive oxidant species (ROS)-decreased inhibitory GABA synaptic transmission in the spinal cord. In this study, we evaluated the analgesic effect of KDS under a new approach, in which KDS acts on dorsal horn sensory neurons to reduce excitatory transmission. Read More

Neurobiol Pain 2022 Aug-Dec;12:100098. Epub 2022 Jun 23.

Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.

Calcitonin gene-related peptide (CGRP) is considered a major player in migraine pathophysiology. However, the location and mechanisms of CGRP actions in migraine are not clearly elucidated. One important question yet to be answered is: Does central CGRP signaling play a role in migraine? One candidate site is the cerebellum, which serves as a sensory and motor integration center and is activated in migraine patients. Read More

Biomed Pharmacother 2022 May 6;149:112915. Epub 2022 Apr 6.

Université Clermont Auvergne, CHU Clermont-Ferrand, Délégation à la Recherche Clinique et à l'Innovation, INSERM U1107 NEURO-DOL, Clermont-Ferrand F-63000, France. Electronic address:

Background: Donepezil, a cholinesterase inhibitor approved in Alzheimer's disease, has demonstrated analgesic and preventive effects in animal models of oxaliplatin-induced neuropathy. To improve the clinical interest of donepezil for the management and prevention of chemotherapy-induced peripheral neuropathy (CIPN), a broader validation is required in different animal models of CIPN.

Methods: using rat models of CIPN (bortezomib, paclitaxel, and vincristine), the analgesic and preventive efficacies of donepezil were evaluated on tactile, cold and heat hypersensitivities. Read More

Front Pain Res (Lausanne) 2022 27;3:872587. Epub 2022 Apr 27.

Department of Anesthesiology and Pain Management, Maastricht University Medical Centre+, Maastricht, Netherlands.

Neonatal painful procedures causes acute pain and trigger long-term changes in nociceptive processing and anxiety behavior, highlighting the need for adequate analgesia during this critical time. Spinal serotonergic receptors 5-HT1a and 5-HT3 play an important role in modulating incoming nociceptive signals in neonates. The current study aims to attenuate acute and long-term hypersensitivity associated with neonatal procedural pain using ondansetron (a 5-HT3 antagonist) and buspirone (a 5-HT1a agonist) in a well-established rat model of repetitive needle pricking. Read More