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Bone 2022 Aug 15:116522. Epub 2022 Aug 15.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School &Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, China. Electronic address:

As the main cells in endochondral osteogenesis, chondrocytes have limited self-repair ability due to weak proliferation activity, low density, and dedifferentiation tendency. Here, a thorough inquiry about the effect and underlying mechanisms of methyltransferase like-3 (Mettl3) on chondrocytes was made. Functionally, it was indicated that Mettl3 promoted the proliferation and hypertrophic differentiation of chondrocytes. Read More

Int J Biol Macromol 2022 Aug 15. Epub 2022 Aug 15.

Department of Joint and Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China. Electronic address:

The alteration of the extracellular matrix (ECM) homeostasis plays an important role in the development of osteoarthritis (OA). The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation. Rebuilding ECM and inhibiting inflammation may reverse OA progression. Read More

Curr Stem Cell Res Ther 2022 Aug 17. Epub 2022 Aug 17.

Department of Orthopedics, The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518052, Guangdong Province, China.

Bone and cartilage regeneration is a dynamic and complex process involving multiple cell types such as osteoblasts, osteoclasts, endothelial cells, etc. Stem cells have been proved with efficient capability to promote bone and cartilage regeneration and repair but the usage of cells harbors some important safety issues, such as immune rejection and carcinogenicity. Exosomes are non-cell structures secreted from various cells. Read More

Am J Sports Med 2022 Aug 17:3635465221111565. Epub 2022 Aug 17.

Department of Orthopaedic Surgery, University of Utah Orthopedic Center, University of Utah, Salt Lake City, Utah, USA.

Background: Abnormal proximal femoral morphology in femoroacetabular impingement syndrome (FAIS) identifiable on the anteroposterior (AP) pelvic radiograph has been described as the "pistol grip" deformity. The effect of a superior cam deformity identified on this radiographic view remains unknown.

Purposes: To assess the relationship between AP cam deformity (AP alpha angle [AP AA] >55°) and cartilage injury; to assess the relationship between AP cam deformity and labral injury; and to determine if patient factors are correlated with cartilage and labral injury. Read More

Biomed Mater 2022 Aug 16. Epub 2022 Aug 16.

Department of Osteoarthropathy, Yantaishan Hospital, No.91, Jiefang Road, Zhifu District, Yantai 264001, Shangdong, P.R.China, Yantai, Shandong, 264001, CHINA.

It is known that an excellent hyaline cartilage phenotype, an internal microstructure with safe crosslinking and available size flexibility are the key factors of cartilage grafts that allow for clinical application. Living hyaline cartilage grafts (LhCGs) constructed by phase-transfer hydrogel (PTCC) systems were reported to have a hyaline phenotype and bionic microstructure. By employing chondrocytes to secrete matrix in the hydrogel and then removing the material to obtain material-free tissue in vitro, LhCG technology exhibited superior performance in cartilage repair. Read More