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Front Genet 2022 14;13:948744. Epub 2022 Jul 14.

Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Angioimmunoblastic T-cell lymphoma (AITL) genomic abnormalities are highly disease-specific, and the ras homology family member A () gene is one of the most recurrent mutated genes, especially for G17V mutation site. Here, we identified a rare A161E mutation in an AITL patient through gene sequencing platforms. The patient presented with persistent hypereosinophilia, asymptomatic or symptomatic mildly for over 3 years. Read More

J Investig Allergol Clin Immunol 2022 Jun 6;32(3):165-180. Epub 2022 May 6.

Department of Immunology, IIS-Fundación Jiménez Díaz; CIBER de Enfermedades Respiratorias (CIBERES) and School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.

Five biological drugs are currently marketed for treatment of uncontrolled severe asthma. They all block type 2 inflammatory pathways by targeting IgE (omalizumab), the IL-5 pathway (mepolizumab, reslizumab, benralizumab), or the IL-4/IL-13 pathway (dupilumab). Hypereosinophilia has been observed in 4%-25% of patients treated with dupilumab and is transient in most cases, although there have been reports of persistent cases of symptomatic hypereosinophilia consistent with eosinophilic granulomatosis with polyangiitis (EGPA), eosinophilic pneumonia, eosinophilic vasculitis, and sudden worsening of asthma symptoms. Read More

World J Clin Cases 2021 Oct;9(28):8571-8578

Department of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, Zhejiang Province, China.

Background: Hypereosinophilia (HE) is defined as a peripheral blood eosinophil count of > 1.5 × 10/L and may be associated with tissue damage. The clinical presentations of HE vary; however, myocardial fibrosis and thrombosis can threaten the lives of patients with sustained eosinophilia. Read More

JAMA Netw Open 2021 08 2;4(8):e2119812. Epub 2021 Aug 2.

Division of Hematology Oncology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.

Importance: Hypereosinophilic syndromes (HESs) are a rare group of disorders that result in overproduction of eosinophils, leading to tissue damage. Thrombotic complications in HES and associated risk factors in this patient population have not been extensively studied.

Objective: To investigate the rates of and risk factors associated with thrombotic events in patients with HES, including markers of clonal hematopoiesis as evidenced by molecular aberrations on next-generation sequencing. Read More

Rinsho Shinkeigaku 2021 May 17;61(5):319-324. Epub 2021 Apr 17.

Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine.

A 61-year-old man was admitted to our hospital due to cerebral infarction in the pons and the right putamen. On admission (day 3 from symptom onset), laboratory testing showed a white blood cell count of 13,100/μl with hypereosinophilia of 3,734/μl. As deep vein thrombosis was detected on contrast-enhanced CT, we started anticoagulation therapy. Read More