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Z Rheumatol 2022 Aug 12. Epub 2022 Aug 12.

Klinik für Rheumatologie und klinische Immunologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Vasculitides are inflammatory diseases of blood vessels caused by autoimmune or infectious processes, which are associated with alterations and destruction of the vascular wall. From a histopathological point of view, granulomatous vasculitides can be distinguished from necrotizing vasculitides with respect to the pattern of inflammation. Granulomatous vasculitides are characterized by intramural, predominantly lymphohistiocytic infiltrates with the formation of giant cells. Read More

Clin Case Rep 2022 Aug 9;10(8):e6231. Epub 2022 Aug 9.

Anatomical and Cytological Pathology Department, Fattouma Bourguiba University Hospital, Faculty of Medicine of Monastir University of Monastir Monastir Tunisia.

Granulomatosis with polyangiitis (GPA) is a systemic necrotizing granulomatous vasculitis, which predominantly affects small-sized blood vessels. We aimed to report a case of GPA involving testicles and epididymis taken for malignancy. A 75-year-old patient was admitted for a painful left testicular mass. Read More

Rheum Dis Clin North Am 2022 Aug 5;48(3):705-724. Epub 2022 Jul 5.

Northwestern University Feinberg School of Medicine, 675 North St. Clair Street, Suite 14-100, Chicago, IL 60611, USA. Electronic address:

The vasculitides encompass a group of inflammatory conditions affecting the blood vessels with severe consequences including tissue ischemia, structural abnormalities, such as aneurysms/dissections, and end organ damage. The different forms are commonly classified based on the size of the blood vessel involved as large-vessel, medium-vessel, and small-vessel vasculitis. The American College of Rheumatology/Vasculitis Foundation recently published guidelines on the management of several forms of primary systemic vasculitides. Read More

Eur Respir J 2022 Aug 11. Epub 2022 Aug 11.

Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, University of Oxford, Oxford, United Kingdom.

The enduring view of eosinophils, as immune effector cells whose primary function is host defence against infection by helminths and other microbial pathogens, sets the stage for a fundamental question regarding the safety of therapeutic eosinophil depletion. If eosinophils are significantly reduced or altogether depleted in an effort to alleviate the negative effects of tissue eosinophilia and eosinophilic inflammation in conditions such as asthma, chronic obstructive pulmonary disease, chronic rhinosinusitis with nasal polyps, eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome, would these patients become susceptible to infection or another illness? Development of mouse models in whom the eosinophil lineage has been ablated, observations in patients naturally lacking eosinophils and data from studies of eosinophil-depleting medical therapies indicate that the absence of eosinophils is not detrimental to health. The evidence available to date, as presented in this review, supports the conclusion that even if certain homeostatic roles for the eosinophil may be demonstrable in controlled animal models and human settings, the evolution of the human species appears to have provided sufficient immune redundancy such that one may be hale and hearty without eosinophils. Read More

Arch Rheumatol 2022 Mar 24;37(1):142-144. Epub 2021 Jun 24.

Department of Pathologic and Topographic Anatomy, P.l. Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine.