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Light and heavy ferritin chain expression in the liver and kidneys of Wistar rats: aging, sex differences, and impact of gonadectomy.

Authors:
Mirela Pavić Vulinović Petra Turčić Vedran Micek Marija Ljubojević

Arh Hig Rada Toksikol 2022 Apr 7;73(1):48-61. Epub 2022 Apr 7.

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Ferritin is the main intracellular storage of iron. Animal studies show that female liver and kidney express more ferritin and accumulate more iron than male. However, no study so far has investigated sex and age differences in light (FtL) and heavy (FtH) ferritin chain expression. To address this, we relied on specific antibodies and immunochemical methods to analyse the expression of both ferritin chains in the liver and kidney of 3-month and 2-year-old male and female Wistar rats. To see how sex hormones may affect expression we also studied adult animals gonadectomised at the age of 10 weeks. FtL and FtH were more expressed in both organs of female rats, while gonadectomy increased the expression in males and decreased it in females, which suggests that it is stimulated by female and inhibited by male steroid hormones. Normal kidney ferritin distribution and change with aging warrant more attention in studies of (patho) physiological and toxicological processes.

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http://dx.doi.org/10.2478/aiht-2022-73-3621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999590PMC
April 2022

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