Aim: The aim of this 12 week, single-blind clinical trial was to compare the efficacy of Manual (Oral-B Pro Health Gum care), Powered (Oral-B Cross action Power Dual) and Charcoal (Colgate slim Soft Charcoal) toothbrushes in plaque control.Materials And Methods: 60 systemically healthy students were selected at random among the students of a Dental College, living under similar environment and dietary conditions. Plaque and calculus were removed professionally and three varieties of toothbrush were distributed among them.