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Orv Hetil 2022 Aug 14;163(33):1311-1317. Epub 2022 Aug 14.

1 Pécsi Tudományegyetem, Szülészeti és Nőgyógyászati Klinika Pécs, Édesanyák útja 17., 7624 Magyarország.

Obesity, as an epidemic, is one of the major public health challenges of the 21st century. It affects more and more people annually, and through its numerous negative psychological and physical effects as a risk factor it increases the morbidity and mortality of several diseases. It has a major impact on pregnancy; it is well established that both infertility and abortion is more common among obese women. Read More

J Biol Chem 2022 Aug 10:102367. Epub 2022 Aug 10.

Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111. Electronic address:

Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway that converts the polyamine synthesis byproduct 5'-deoxy-5'-methylthioadenosine (MTA) into methionine. Inactivation of MTAP, often by homozygous deletion, is found in both solid and hematologic malignancies and is one of the most frequently observed genetic alterations in human cancer. Previous work established that MTAP-deleted cells accumulate MTA and contain decreased amounts of proteins with arginine residues symmetrically dimethylated (sDMA). Read More

Biomater Adv 2022 Jul 26;140:213045. Epub 2022 Jul 26.

School of Dentistry and Graduate Institute of Clinical Dentistry, National Taiwan University and National Taiwan University Hospital, Taipei 10016, Taiwan; School of Dentistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Electronic address:

Vital pulp therapy (VPT) has gained significant consideration by utilizing the natural healing capacity of the inflamed pulp in healing process. However, the protective pulp capping materials that facilitate this healing process are still under investigation for the successful promotion of dentin-pulp regeneration. Herein, we developed a bioactive and biodegradable pulp capping material (denoted as sCSHA-GFs) by synthesizing inorganic submicron calcium sulfate hemihydrate (sCS)/porous hydroxyapatite (HA) loaded with growth factors (GFs) such as transforming growth factor-beta 1 (TGF-β1), fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF). Read More

J Dent Res Dent Clin Dent Prospects 2022 29;16(1):40-44. Epub 2022 May 29.

Department of Endodontics, Faculty of Dentistry, Shahid Beheshti Medical University, Tehran, Iran.

The bond strength of the materials used as a cervical barrier in the pulp regeneration is essential for the success of treatment. This study aimed to evaluate the effects of triple antibiotic paste (TAP), double antibiotic paste (DAP), and simvastatin as intracanal medicaments on the dislodgement resistance of mineral trioxide aggregate (MTA) and calcium-enriched mixture (CEM). A total of 160 extracted human single-rooted teeth were selected, and root canal preparation was carried out. Read More

Eur J Cancer 2022 Aug 3;173:210-218. Epub 2022 Aug 3.

Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Purpose: Anaplastic thyroid cancer (ATC) is a rare and highly aggressive cancer for which effective systemic therapy has long been sought. Here, we assessed the efficacy and safety of lenvatinib in patients with unresectable ATC.

Patients And Methods: The study was investigator-initiated and conducted under a multicenter, open-label, nonrandomized, phase II design. Read More