Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

Spontaneous generation of persistent activity in diffusively coupled cellular assemblies.

Authors:
Ria Ghosh Shakti N Menon

Phys Rev E 2022 Jan;105(1-1):014311

The Institute of Mathematical Sciences, CIT Campus, Taramani, Chennai 600113, India.

The spontaneous generation of electrical activity underpins a number of essential physiological processes, and is observed even in tissues where specialized pacemaker cells have not been identified. The emergence of periodic oscillations in diffusively coupled assemblies of excitable and electrically passive cells (which are individually incapable of sustaining autonomous activity) has been suggested as a possible mechanism underlying such phenomena. In this paper we investigate the dynamics of such assemblies in more detail by considering simple motifs of coupled electrically active and passive cells. The resulting behavior encompasses a wide range of dynamical phenomena, including chaos. However, embedding such assemblies in a lattice yields spatiotemporal patterns that either correspond to a quiescent state or to partial or globally synchronized oscillations. The resulting reduction in dynamical complexity suggests an emergent simplicity in the collective dynamics of such large, spatially extended systems. Furthermore, we show that such patterns can be reproduced by a reduced model comprising only excitatory and oscillatory elements. Our results suggest a generalization of the mechanism by which periodic activity can emerge in a heterogeneous system comprising nonoscillatory elements by coupling them diffusively, provided their steady states in isolation are sufficiently dissimilar.

Download full-text PDF

Source
http://dx.doi.org/10.1103/PhysRevE.105.014311DOI Listing
January 2022

Publication Analysis

Top Keywords

passive cells
8
spontaneous generation
8
diffusively coupled
8
globally synchronized
4
partial globally
4
state partial
4
quiescent state
4
correspond quiescent
4
patterns correspond
4
phenomena including
4
spatiotemporal patterns
4
yields spatiotemporal
4
lattice yields
4
assemblies lattice
4
embedding assemblies
4
synchronized oscillations
4
chaos embedding
4
including chaos
4
isolation dissimilar
4
dynamical phenomena
4

Keyword Occurance

Similar Publications

The role of ion-lipid interactions and lipid packing in ion-induced pores and transient defects caused by phenolic compounds.

Authors:
Sheikh I Hossain Mathilda Seppelt Natalie Nguyen Chelsea Stokes Evelyne Deplazes

Biophys J 2022 Aug 4. Epub 2022 Aug 4.

The transient disruption of membranes for the passive permeation of ions or small molecules is a complex process relevant to understanding physiological processes and biotechnology applications. Phenolic compounds are widely studied for their antioxidant and antimicrobial properties, and many biological activities of phenolic compounds are based on their interactions with membranes. Ions are ubiquitous in cells and are known to alter the structure of phospholipid bilayers. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Strategies to mitigate the on- and off-target toxicities of recombinant immunotoxins: an antibody engineering perspective.

Authors:
Mengyu Li Sen Mei Yi Yang Yuelei Shen Lei Chen

Antib Ther 2022 Jul 16;5(3):164-176. Epub 2022 Jun 16.

Biotherapeutics, Biocytogen Jiangsu Co. Ltd, Nantong, China.

Targeted cancer therapies using immunotoxins have achieved remarkable efficacy in hematological malignancies. However, the clinical development of immunotoxins is also faced with many challenges like anti-drug antibodies and dose-limiting toxicity issues. Such a poor efficacy or safety ratio is also the major hurdle in the research and development of antibody-drug conjugates. Read More

View Article and Full-Text PDF
July 2022
Similar Publications

Functional reorganization of monoamine transport systems during villous trophoblast differentiation: evidence of distinct differences between primary human trophoblasts and BeWo cells.

Authors:
Veronika Vachalova Rona Karahoda Martina Ottaviani Kasin Yadunandam Anandam Cilia Abad Christiane Albrecht Frantisek Staud

Reprod Biol Endocrinol 2022 Aug 4;20(1):112. Epub 2022 Aug 4.

Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.

Background: Three primary monoamines-serotonin, norepinephrine, and dopamine-play major roles in the placenta-fetal brain axis. Analogously to the brain, the placenta has transport mechanisms that actively take up these monoamines into trophoblast cells. These transporters are known to play important roles in the differentiated syncytiotrophoblast layer, but their status and activities in the undifferentiated, progenitor cytotrophoblast cells are not well understood. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

The imaging of the hypoxic microenvironment in tumorous tissue using PET/CT and PET/MRI.

Authors:
Jiří Ferda Eva Ferdová Martin Vítovec David Glanc Hynek Mírka

Eur J Radiol 2022 Jul 29;154:110458. Epub 2022 Jul 29.

Department of the Imaging, University Hospital Pilsen, Charles University, Medical Faculty in Pilsen, Alej Svobody 80, 304 60 Pilsen, Czechia.

Tissue hypoxia becomes the driver of the micro-environmental transformation of the malignant tumorous tissue in majority of solid tumors. Even more, during the development of solid tumors, a large amount of nutrients is consumed due to rapid proliferation of tumor cells. The way of use of nutrients could be assessed using the probes during positron emission tomography (PET), the most frequent is the use of F-fluorodeoxyglucose (F-FDG) demonstrating the turn-over of glucose exploitation in a manner of Warburg phenomenon. Read More

View Article and Full-Text PDF
July 2022
Similar Publications

Direct constraint control for EM-based miniaturization of microwave passives.

Authors:
Slawomir Koziel Anna Pietrenko-Dabrowska

Sci Rep 2022 Aug 3;12(1):13320. Epub 2022 Aug 3.

Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, 80-233, Gdansk, Poland.

Handling constraints imposed on physical dimensions of microwave circuits has become an important design consideration over the recent years. It is primarily fostered by the needs of emerging application areas such as 5G mobile communications, internet of things, or wearable/implantable devices. The size of conventional passive components is determined by the guided wavelength, and its reduction requires topological modifications, e. Read More

View Article and Full-Text PDF
August 2022
Similar Publications
}
© 2022 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap