Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

Burden of Kaposi sarcoma according to HIV status: A systematic review and global analysis.

Authors:
Ahmadaye Ibrahim Khalil Silvia Franceschi Catherine de Martel Freddie Bray Gary M Clifford

Int J Cancer 2022 06 16;150(12):1948-1957. Epub 2022 Feb 16.

Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.

In 2020, over 34 000 cases of Kaposi sarcoma (KS) were estimated globally, all attributable to KS herpesvirus (KSHV). Prior to the HIV epidemic, KS already existed in KSHV endemic regions, notably in sub-Saharan Africa (SSA). The HIV epidemic has vastly increased the KS burden. We developed a methodology to provide global estimates of KS burden according to HIV status. A systematic review identified studies reporting HIV prevalence in consecutive KS series. Pooled estimates of HIV prevalence, by country or UN subregion, were used to calculate population-attributable fraction (PAF) and these were applied to IARC's GLOBOCAN 2020 to estimate burden and incidence of HIV-attributable and non-HIV-attributable KS. We identified 55 eligible studies, reporting HIV prevalence ranging from ≤5% to ≥95%. Approximately 80% of KS in SSA was estimated attributable to HIV, vs ~50% in the rest of the world. By applying PAFs to national GLOBOCAN estimates, an estimated 19 560 KS cases attributable to HIV were diagnosed in SSA in 2020 (~80% of the worldwide burden), vs 5064 cases of non-HIV-attributable KS (~60% of the worldwide burden). Incidence of HIV-attributable KS was highest in Southern Africa (6.0 cases per 100 000) and Eastern Africa (3.4), which were also the world regions with highest incidence of non-HIV-attributable KS (0.4 and 1.0 cases per 100 000, respectively). This first systematic effort to produce a global picture of KS burden stratified by HIV status highlights the continuing important burden of HIV-attributable KS in SSA, even in the era of combined antiretroviral therapy.

Download full-text PDF

 Source
http://dx.doi.org/10.1002/ijc.33951DOI Listing
June 2022

Publication Analysis

Top Keywords

hiv prevalence
12
hiv status
12
hiv
10
systematic review
8
incidence hiv-attributable
8
burden incidence
8
attributable hiv
8
hiv epidemic
8
studies reporting
8
reporting hiv
8
burden
8
worldwide burden
8
status systematic
8
kaposi sarcoma
8
cases 100 000
8
cases
5
~50% rest
4
≤5% ≥95%
4
pafs national
4
national globocan
4

Keyword Occurance

Similar Publications

Musculoskeletal tuberculosis in Bradford : 12 years of outcomes and observations in a high-incidence region of the UK.

Authors:
Andrew D Craig Samir Asmar Paul Whitaker David L Shaw Dinesh Saralaya

Bone Jt Open 2022 May;3(5):432-440

Department of Respiratory Medicine, Bradford Royal Infirmary, Bradford, UK.

Aims: Tuberculosis (TB) is one of the biggest communicable causes of mortality worldwide. While incidence in the UK has continued to fall since 2011, Bradford retains one of the highest TB rates in the UK. This study aims to examine the local disease burden of musculoskeletal (MSK) TB, by analyzing common presenting factors within the famously diverse population of Bradford. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Isoniazid preventive therapy and TB transcriptional signatures in people with HIV.

Authors:
Ethan D Valinetz Daniel Matemo Jill K Gersh Lara L Joudeh Simon C Mendelsohn Thomas J Scriba Mark Hatherill John Kinuthia Anna Wald Gerard A Cangelosi Ruanne V Barnabas Thomas R Hawn David J Horne

AIDS 2022 May 24. Epub 2022 May 24.

Department of Medicine, University of Washington, Seattle, WA.

Objectives: To examine the association between isoniazid preventive therapy (IPT) or nontuberculous mycobacteria (NTM) sputum culture positivity and tuberculosis (TB) transcriptional signatures in people with HIV.

Design: Cross-sectional study.

Methods: We enrolled adults living with HIV who were IPT-naive or had completed IPT more than 6 months prior at HIV care clinics in western Kenya. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Long-term HIV treatment outcomes and associated factors in sub-Saharan Africa: multi-country longitudinal cohort analysis.

Authors:
Seth C Inzaule Stefanie Kroeze Cissy M Kityo Margaret Siwale Sulaimon Akanmu Maureen Wellington Marleen de Jager Prudence Ive Kishor Mandaliya Wendy Stevens Kim Steegen Immaculate Nankya T Sonia Boender Pascale Ondoa Kim C E Sigaloff Tobias F Rinke de Wit Raph L Hamers

AIDS 2022 May 24. Epub 2022 May 24.

Amsterdam Institute for Global Health and Development, and Department of Global Health, Amsterdam UMC, University of Amsterdam.

Objective: In a multicountry prospective cohort of persons with HIV from six countries between 2007 and 2015, we evaluated long-term outcomes of first-line non-nucleoside reverse-transcriptase inhibitor-based antiretroviral therapy (ART), and risk factors for loss-to-follow-up, mortality, virological failure, and incomplete CD4+ T-cell recovery.

Methods: We calculated cumulative incidence of lost-to-follow-up, death, virological failure (VL ≥ 1000 cps/ml) and incomplete CD4+ T-cell recovery (<500 cells/μl) at successive years, using Kaplan-Meier and Cox regression.

Results: Of 2735 participants, 58. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Incident depression among Medicare beneficiaries with disabilities and HIV.

Authors:
Xiaoying Yu Jacques Baillargeon Abbey B Berenson Jordan R Westra Thomas P Giordano Yong-Fang Kuo

AIDS 2022 May 24. Epub 2022 May 24.

Department of Preventive Medicine and Population Health.

Objective: Despite disproportionally high prevalence of HIV and depression in persons with disabilities, no data have been published on the incidence and correlates of depression in Medicare beneficiaries with disabilities. We assessed the effect of HIV infection on developing depression in this population.

Design: We conducted a retrospective matched cohort study using a 5% sample of Medicare beneficiaries who qualified for disability coverage (1996-2015). Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Adverse perinatal outcomes associated with HAART and monotherapy: systematic review and meta-analysis.

Authors:
Clara Portwood Harriet Sexton Mary Kumarendran Zoe Brandon Shona Kirtley Joris Hemelaar

AIDS 2022 May 24. Epub 2022 May 24.

National Perinatal Epidemiology Unit, Nuffield Department of Population Health.

Objectives: Assess adverse perinatal outcomes in women living with HIV (WLHIV) receiving HAART or zidovudine (ZDV) monotherapy, compared with antiretroviral therapy (ART)-naive WLHIV and HIV-negative women.

Design: Systematic review and meta-analysis.

Methods: We conducted a systematic literature review by searching PubMed, CINAHL, Global Health, and EMBASE for studies published during 1 January 1980 to 20 April 2020. Read More

View Article and Full-Text PDF
May 2022
Similar Publications
}