Postoperative administration of ketorolac compared to other drugs for pain control after third molar surgery: A meta-analysis of double-blind, randomized, clinical trials.

Authors:

Mario Alberto Isiordia-Espinoza Ángel Josabad Alonso-Castro Nicolás Serafín-Higuera Demian Ismael Castañeda-Santana Maximiliano de la Rosa Coronado Ronell Eduardo Bologna-Molina

Br J Clin Pharmacol 2022 Jun 7;88(6):2591-2604. Epub 2022 Feb 7.

Patología Molecular, Facultad de Odontología, Universidad de la República (UDELAR), Montevideo, Uruguay.

Aims: The aim of this study was to evaluate the analgesic effectiveness and adverse reactions of ketorolac in comparison with other drugs when administered postoperatively after third molar surgery.

Methods: PubMed and Google Scholar were utilized to search for articles comparing the efficacy and safety of ketorolac and other analgesic agents after third molar surgery. Data from papers with a lower risk of bias were recorded. The overall evaluation of analgesia onset, general and subgroup evaluation of the number of patients requiring rescue analgesic medication, general and subgroup assessment of the study medication (satisfaction on the study drugs), and the overall estimation of adverse effects were performed using the Review Manager Software 5.3 to analyse the data and obtain the meta-analysis plot.

Results: The subgroup evaluation of the study medication showed that patients who received ketorolac 30 mg were more satisfied than those who were given parecoxib 1 mg (odds ratio [OR] = 8.57, 95% confidence interval [CI] = 3.66-20.08, P = .00001), parecoxib 2 mg (OR = 7.17, 95% CI = 2.88-17.86, P = .0001), parecoxib 5 mg (OR = 3.03, 95% CI = 1.69-5.41, P = .0002), and parecoxib 10 mg (OR = 2.42, 95% CI = 1.36-4.32, P = .003). Moreover, patients who received ketorolac reported fewer adverse reactions compared with those who had received opioid analgesics (OR = 0.14, 95% CI = 0.32-1.76, P = .0001).

Conclusions: The data from this study demonstrates that the postoperative administration of ketorolac 30 mg presents better results on patient satisfaction when compared to parecoxib 1 mg to 10 mg, and presents a similar satisfaction to parecoxib 20 mg following third molar removal.

Download full-text PDF	Source
http://dx.doi.org/10.1111/bcp.15241	DOI Listing

June 2022

Publication Analysis

Keyword Occurance

Similar Publications

Anatomical limitations and factors influencing molar distalization.

Authors:

Victoria Lee Zhi Hui Yaxin Xie Kaiwen Zhang Haoran Chen Wenze Han Ye Tian Yijia Yin Xianglong Han

Angle Orthod 2022 May 23. Epub 2022 May 23.

Objectives: To analyze the anatomical limitations and characteristics of maxillary and mandibular retromolar regions affecting molar distalization using cone-beam computed tomography (CBCT).

Materials And Methods: A total of 120 qualifying patients were classified into equal groups of skeletal Class II and Class III and stratified by vertical growth pattern, age, sex, and third molar presence. The available distance along the axis of distalization and cortical bone thickness (CBT) were measured in the maxillary and mandibular retromolar regions of Class II and Class III patients, respectively. Read More

View Article and Full-Text PDF

May 2022

Similar Publications

External validation of cone-beam computed tomography- and panoramic radiography-featured prediction models for inferior alveolar nerve injury after lower third molar removal: proposal of a risk calculator.

Authors:

Seiko Kubota Tomoaki Imai Ayano Nishimoto Shigeki Amekawa Narikazu Uzawa

Odontology 2022 May 23. Epub 2022 May 23.

Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.

We previously developed basic and extended models to predict inferior alveolar nerve injuries (IANI) after lower third molar (LM3) removal based on cone-beam computed tomography (CBCT) images. Although these models comprised predictors, including increased age and inferior alveolar canal-related CBCT factors, external validations were lacking. Therefore, this study externally validated these models and compared them with other related models based on their performance. Read More

View Article and Full-Text PDF

May 2022

Similar Publications

Early root migration after a mandibular third molar coronectomy.

Authors:

Rashida N Simons Jacco G Tuk Jean-Pierre T F Ho Naichuan Su Jerome A Lindeboom

Oral Maxillofac Surg 2022 May 21. Epub 2022 May 21.

Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center and Amstelland Hospital, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.

Purpose: This prospective cohort study aimed to assess early root migration after a coronectomy of the mandibular third molar at 2 and 6 months after surgery.

Methods: We included all patients treated with a coronectomy of an impacted mandibular third molar. The primary outcome measure was the extent of postoperative root migration after 2 and 6 months. Read More

View Article and Full-Text PDF

May 2022

Similar Publications

[Vitamin supply of patients with type 2 diabetes mellitus complicated by nephropathy].

Authors:

O A Vrzhesinskaya S N Leonenko V M Kodentsova N A Beketova O V Kosheleva V V Pilipenko O A Plotnikova R I Alekseeva Kh Kh Sharafetdinov

Vopr Pitan 2022 14;91(2):58-71. Epub 2022 Mar 14.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.

Insufficient vitamin content in the diet is a risk factor for the development of various diseases and their progression, and drug therapy can also contribute to the development of a deficiency of these micronutrients. Data on vitamin sufficiency of patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) are needed to develop measures to improve it. of the research was to compare vitamin status of patients with T2DM without DN and those with T2DM complicated by nephropathy by assessing vitamin blood level and urinary excretion. Read More

View Article and Full-Text PDF

March 2022

Similar Publications

Randomized split-mouth study for evaluating the efficacy of nimesulide and nimesulide + Thiocolchicoside combination following impacted mandibular third molar surgery.

Authors:

M B Kasapoglu A T Cebi

Niger J Clin Pract 2022 May;25(5):641-646

Department of Oral and Maxillofacial Surgery, Karabuk University, Faculty of Dentistry, Demir Çelik Kampüsü 78050 Karabuk, Turkey.

Background And Aim: This study aimed to evaluate acute postoperative pain management and trismus in 35 patients undergoing extractions of the two mandibular third molars, in mesioangular positions, at two different visits who consumed nimesulide + thiocolchicoside or only nimesulide.

Material And Methods: According to the medication given, the patients were divided into two groups. Following the first surgery of the impacted third molar patients were given nimesulide (100 mg) + thiocolchicoside (8 mg) together. Read More

View Article and Full-Text PDF

May 2022

Similar Publications

}

Search Our Scientific Publications & Authors