Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

A model for predicting gestational diabetes mellitus in early pregnancy: a prospective study in Thailand.

Authors:
Sattamat Lappharat Penkae Rothmanee Kasemsak Jandee Manaphat Suksai Tippawan Liabsuetrakul

Obstet Gynecol Sci 2022 Mar 26;65(2):156-165. Epub 2022 Jan 26.

Department of Epidemiology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Objective: To develop a predictive model using the risk factors of gestational diabetes mellitus (GDM) and construct a predictive nomogram for GDM risk in women during early pregnancy.

Methods: A prospective study was conducted in two tertiary hospitals among pregnant women with gestational age ≤14 weeks. Early GDM was diagnosed if an abnormal 100 g oral glucose tolerance test was detected using the Carpenter and Coustan criteria after an abnormal 50 g glucose challenge test. The factors included in the model were ACOG risk factors; maternal age; family history of hypertensive disorder in pregnancy; family history of dyslipidemia; gravida; parity; histories of preterm birth, early fetal death, abortion, stillbirth, and low birth weight; and glycated hemoglobin (HbA1c) levels. The predictive models for early GDM were analyzed using multiple logistic regression analyses. The nomograms were constructed, and their discrimination ability and predictive accuracy were tested.

Results: Of the 553 pregnant women, 54 (9.8%) were diagnosed with early GDM. In the integrated model, there was a history of GDM (adjusted odds ratio [aOR], 5.15; 95% confidence interval [CI], 1.82-14.63; P=0.004), HbA1c threshold ≥5.3% (aOR, 2.61; 95% CI, 1.44-4.74; P=0.002), and family history of dyslipidemia (aOR, 2.68; 95% CI, 1.37-5.21; P=0.005). The integrated nomogram model showed that a history of GDM had a high impact on the risk of early GDM. Its discrimination and mean absolute error were 0.76 and 0.009, respectively.

Conclusion: Application of the predictive model and nomogram will help healthcare providers investigate the probability of early GDM, especially in resource-limited countries.

Download full-text PDF

 Source
http://dx.doi.org/10.5468/ogs.21250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942750PMC
March 2022

Publication Analysis

Top Keywords

early gdm
20
family history
12
gdm
9
pregnant women
8
prospective study
8
history dyslipidemia
8
gestational diabetes
8
model history
8
diabetes mellitus
8
early
8
history gdm
8
risk factors
8
predictive model
8
model
6
predictive
5
history
5
application predictive
4
discrimination ability
4
gdm analyzed
4
analyzed multiple
4

Keyword Occurance

Similar Publications

Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes.

Authors:
David Karasek Ondrej Krystynik Veronika Kucerova Dominika Macakova Lubica Cibickova Jan Schovanek Martin Haluzik

J Clin Med 2022 Apr 25;11(9). Epub 2022 Apr 25.

Diabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.

Background: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), and fibroblast growth factor-19 (FGF-19) belong to proteins involved in glucose metabolism regulation. The aims of the study were to compare the plasma levels of these proteins in women with early diagnosed gestational diabetes mellitus (GDM) to those in healthy controls and to investigate their changes during pregnancy after early intervention.

Methods: The study was undertaken as a case-control study. Read More

View Article and Full-Text PDF
April 2022
Similar Publications

First-trimester maternal serum betatrophin levels are decreased in pregnancies complicated by gestational diabetes mellitus.

Authors:
Mehmet Mete Kirlangic Mefkure Eraslan Sahin Erdem Sahin Yusuf Madendag Ilknur Col Madendag Esra Akdemir Merve Vural Yalman

Placenta 2022 May 8;124:1-4. Epub 2022 May 8.

Department of Obstetrics and Gynecology, Terme Government Hospital, Samsun, Turkey.

Introduction: The purpose of the present study was to compare maternal serum betatrophin levels during the first trimester from healthy pregnancies to those complicated by gestational diabetes mellitus (GDM).

Methods: In this prospective study, 320 pregnant women were evaluated in their first trimester, and 145 pregnant women who met the inclusion criteria were divided into the following two groups according to GDM screening results: GDM (n:20) and non-diabetic healthy control (n: 125). Samples of maternal serum fasting insulin, fasting blood glucose, hemoglobin (HB)A1c, and betatrophin levels obtained from the women's blood samples between 11 -13 gestational weeks during first trimester nuchal translucency screening. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women.

Authors:
Caihong Luo Zhiju Li Yunya Lu Fang Wei Dongmei Suo Shiyan Lan Zhengyuan Ren Runchang Jiang Fang Huang Aiyue Chen Liejun Jiang Huayi Huang Xiaoling Guo

BMC Pregnancy Childbirth 2022 May 11;22(1):400. Epub 2022 May 11.

Department of Obstetrics, Southern Medical University Affiliated Maternal & Children's Hospital of Foshan, No. 11 Renminxi Road, Foshan, Guangdong, 528000, China.

Background: The association between serum 25-hydroxy vitamin D (25(OH)D) status and gestational diabetes mellitus (GDM) gained attention in recent years, however the conclusion is still controversial due to many interfering factors, such as region of living, environment, lifestyle, and food supplements. Other metabolites (laboratory parameters) are also important in reflecting gestational states. This study aimed to investigate the association of serum 25(OH)D status in early pregnancy with GDM and other laboratory parameters in pregnant women. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Gestational Diabetes Mellitus pregnancy by pregnancy: early, late and nonrecurrent GDM.

Authors:
Chiara Giuliani Laura Sciacca Nicolina Di Biase Andrea Tumminia Agostino Milluzzo Antongiulio Faggiano Francesca Romana Amorosi Alessio Convertino Olimpia Bitterman Camilla Festa Angela Napoli

Diabetes Res Clin Pract 2022 May 7;188:109911. Epub 2022 May 7.

Department of Clinical and Molecular Medicine Sapienza University of Rome, Rome, Italy; Israelitico Hospital, Rome, Italy; Santa Famiglia CdC, Rome, Italy.

Aims: To assess the GDM recurrence rate in a cohort of pregnant women with prior GDM, to compare two consecutive pregnancies complicated by GDM, to compare women with nonrecurrent and recurrent GDM and to stratify the latter in women with early and late recurrent GDM.

Methods: Retrospective study including 113 women with GDM in an index pregnancy (G1), at least a postindex pregnancy (G2) and normal glucose tolerance in between. The GDM recurrence rate was assessed, and maternal and neonatal outcomes and pancreatic beta cell function of the index pregnancy were compared with those of the postindex pregnancy (G1 vs. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Impact of earlier gestational diabetes screening for pregnant people with obesity on maternal and perinatal outcomes.

Authors:
Teresa A Hillier Kathryn L Pedula Keith K Ogasawara Kimberly K Vesco Caryn Oshiro Jan L Van Marter

J Perinat Med 2022 May 11. Epub 2022 May 11.

Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.

Objectives: Gestational diabetes (GDM) screening at 24-28 weeks' gestation reduces risk of adverse maternal and perinatal outcomes. While experts recommend first-trimester screening for high-risk patients, including those with obesity, data supporting this recommendation is limited.

Methods: We implemented a systematic population intervention to encourage first-trimester GDM screening by oral glucose tolerance testing in a cohort of pregnant people with obesity in two integrated health systems from 2009 to 2013, and compared outcomes to the same population pre-intervention (2006-2009). Read More

View Article and Full-Text PDF
May 2022
Similar Publications
}