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Paediatr Anaesth 2022 May 22. Epub 2022 May 22.

Consultant paediatric cardiac anaesthetist, Royal Hospital for Children, Glasgow.

Over-fasting before surgery can lead to dehydration, irritability, lethargy, nausea, hypoglycaemia, tricky intravenous cannulation and decreased patient satisfaction . We used 'Kotter's 8 steps for change' as an approach to tackling the problem of over-fasting in our day surgery unit . Using a video of a patient's experience with overfasting we created a sense of urgency and need for change (Step1: create urgency). Read More

Eur J Clin Invest 2022 May 22:e13818. Epub 2022 May 22.

Division of Laboratory Medicine, Department of Diagnostics and of Medical Specialties, Geneva University Hospitals and Geneva University, Geneva, Switzerland.

Background: SARS-CoV-2 infection triggers different auto-antibodies, including anti-apolipoprotein A-1 IgGs (AAA1), which could be of concern as mediators of persistent symptoms. We determined the kinetics of AAA1 response over after COVID-19, and the impact of AAA1 on the inflammatory response and symptoms persistence.

Methods: All serologies were assessed at one, three, six, and twelve months in 193 hospital employees with COVID-19. Read More

Mycoses 2022 May 22. Epub 2022 May 22.

School of Medicine and Centre for Interventions in Infection, Inflammation, and Immunity (4i), University of Limerick, Limerick, Ireland.

Background: Fungal skin infections are recognised as one of the most common health disorders globally, and dermatophyte infections of the skin, hair and nails are the most common fungal infections. Dermatophytes can be classified as anthropophilic, zoophilic or geophilic species based on their primary habitat association, and this classification makes epidemiological analysis useful for prevention and control of these infections. The Irish contribution to the epidemiology of these infections has been scant, with just two papers (both reporting paediatric tinea capitis only) published in the last 20 years, and none in the last seven. Read More

Eur J Clin Invest 2022 May 22:e13815. Epub 2022 May 22.

Centre for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI) and University of Trieste, Trieste, Italy.

Background: Prognostic stratification of acute myocarditis (AM) presenting with normal left ventricular ejection fraction (LVEF) relies mostly on late gadolinium enhancement (LGE) characterization. Left ventricular peak global longitudinal strain (LV-GLS) measured by feature tracking analysis might improve prognostication of AM presenting with normal LVEF.

Methods: Data of patients undergoing cardiac magnetic resonance (CMR) for clinically suspected AM in seven European Centres (2013-2020) were retrospectively analysed. Read More

Cancer Sci 2022 May 22. Epub 2022 May 22.

Department of Radiation Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, P. R. China.

Programmed cell death ligand 1 (PD-L1) is an immune surface protein that binds to programmed cell death 1 (PD-1) and allows tumors to evade T cell immunity. This study aims to define the role of PD-L1 shuttled by tumor cell-derived exosomes in the immune escape of nasopharyngeal carcinoma (NPC). PD-L1 expression was determined in the exosomes isolated from the plasma of NPC patients or from NPC cells. Read More