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Detection of breast cancer by ATR-FTIR spectroscopy using artificial neural networks.

Authors:
Rock Christian Tomas Anthony Jay Sayat Andrea Nicole Atienza Jannah Lianne Danganan Ma Rollene Ramos Allan Fellizar Kin Israel Notarte Lara Mae Angeles Ruth Bangaoil Abegail Santillan Pia Marie Albano

PLoS One 2022 26;17(1):e0262489. Epub 2022 Jan 26.

Department of Biological Sciences, College of Science, University of Santo Tomas, Manila, Philippines.

In this study, three (3) neural networks (NN) were designed to discriminate between malignant (n = 78) and benign (n = 88) breast tumors using their respective attenuated total reflection Fourier transform infrared (ATR-FTIR) spectral data. A proposed NN-based sensitivity analysis was performed to determine the most significant IR regions that distinguished benign from malignant samples. The result of the NN-based sensitivity analysis was compared to the obtained results from FTIR visual peak identification. In training each NN models, a 10-fold cross validation was performed and the performance metrics-area under the curve (AUC), accuracy, positive predictive value (PPV), specificity rate (SR), negative predictive value (NPV), and recall rate (RR)-were averaged for comparison. The NN models were compared to six (6) machine learning models-logistic regression (LR), Naïve Bayes (NB), decision trees (DT), random forest (RF), support vector machine (SVM) and linear discriminant analysis (LDA)-for benchmarking. The NN models were able to outperform the LR, NB, DT, RF, and LDA for all metrics; while only surpassing the SVM in accuracy, NPV and SR. The best performance metric among the NN models was 90.48% ± 10.30% for AUC, 96.06% ± 7.07% for ACC, 92.18 ± 11.88% for PPV, 94.19 ± 10.57% for NPV, 89.04% ± 16.75% for SR, and 94.34% ± 10.54% for RR. Results from the proposed sensitivity analysis were consistent with the visual peak identification. However, unlike the FTIR visual peak identification method, the NN-based method identified the IR region associated with C-OH C-OH group carbohydrates as significant. IR regions associated with amino acids and amide proteins were also determined as possible sources of variability. In conclusion, results show that ATR-FTIR via NN is a potential diagnostic tool. This study also suggests a possible more specific method in determining relevant regions within a sample's spectrum using NN.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262489PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791515PMC
February 2022

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