Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

A programmable and skin temperature-activated electromechanical synergistic dressing for effective wound healing.

Authors:
Guang Yao Xiaoyi Mo Chenhui Yin Wenhao Lou Qian Wang Sirong Huang Linna Mao Sihong Chen Kangning Zhao Taisong Pan Lin Huang Yuan Lin

Sci Adv 2022 Jan 26;8(4):eabl8379. Epub 2022 Jan 26.

School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.

Mechanical regulation and electric stimulation hold great promise in skin tissue engineering for manipulating wound healing. However, the complexity of equipment operation and stimulation implementation remains an ongoing challenge in clinical applications. Here, we propose a programmable and skin temperature-activated electromechanical synergistic wound dressing composed of a shape memory alloy-based mechanical metamaterial for wound contraction and an antibacterial electret thin film for electric field generation. This strategy is successfully demonstrated on rats to achieve effective wound healing in as short as 4 and 8 days for linear and circular wounds, respectively, with a statistically significant over 50% improvement in wound closure rate versus the blank control group. The optimally designed electromechanical synergistic stimulation could regulate the wound microenvironment to accelerate healing metabolism, promote wound closure, and inhibit infection. This work provided an effective wound healing strategy in the context of a programmable temperature-responsive, battery-free electromechanical synergistic biomedical device.

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.abl8379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791608PMC
January 2022

Publication Analysis

Top Keywords

electromechanical synergistic
16
wound healing
16
effective wound
12
wound
9
wound closure
8
skin temperature-activated
8
temperature-activated electromechanical
8
programmable skin
8
healing
5
achieve effective
4
healing short
4
short days
4
linear circular
4
days linear
4
demonstrated rats
4
circular wounds
4
wounds statistically
4
statistically 50%
4
50% improvement
4
improvement wound
4

Keyword Occurance

Similar Publications

Sustainable-Macromolecule-Assisted Preparation of Cross-linked, Ultralight, Flexible Graphene Aerogel Sensors toward Low-Frequency Strain/Pressure to High-Frequency Vibration Sensing.

Authors:
Zhihui Zeng Na Wu Weidong Yang Hao Xu Yaozhong Liao Chenwei Li Mirko Luković Yunfei Yang Shanyu Zhao Zhongqing Su Xuehong Lu

Small 2022 May 16:e2202047. Epub 2022 May 16.

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.

Ultralight and highly flexible aerogel sensors, composed of reduced graphene oxide cross-linked by sustainable-macromolecule-derived carbon, are prepared via facile freeze-drying and thermal annealing. The synergistic combination of cross-linked graphene nanosheets and micrometer-sized honeycomb pores gives rise to the exceptional properties of the aerogels, including superior compressibility and resilience, good mechanical strength and durability, satisfactory fire-resistance, and outstanding electromechanical sensing performances. The corresponding aerogel sensors, operated at an ultralow voltage of 0. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Hybridized Frequency Combs in Multimode Cavity Electromechanical System.

Authors:
Sishi Wu Yulong Liu Qichun Liu Shuai-Peng Wang Zhen Chen Tiefu Li

Phys Rev Lett 2022 Apr;128(15):153901

Beijing Academy of Quantum Information Sciences, Beijing 100193, China.

The cavity electromechanical devices with radiation-pressure interaction induced Kerr-like nonlinearity are promising candidates to generate microwave frequency combs. We construct a silicon-nitride membrane based superconducting cavity electromechanical device and study two mechanical modes synergistic frequency combs. Around the threshold of intracavity field instability, we first show independent frequency combs with tooth spacing equal to each mechanical mode frequency. Read More

View Article and Full-Text PDF
April 2022
Similar Publications

Ultrahigh Piezoelectric Performance through Synergistic Compositional and Microstructural Engineering.

Authors:
Yongke Yan Liwei D Geng Li-Feng Zhu Haoyang Leng Xiaotian Li Hairui Liu Dabin Lin Ke Wang Yu U Wang Shashank Priya

Adv Sci (Weinh) 2022 May 16;9(14):e2105715. Epub 2022 Mar 16.

Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA, 16802, USA.

Piezoelectric materials enable the conversion of mechanical energy into electrical energy and vice-versa. Ultrahigh piezoelectricity has been only observed in single crystals. Realization of piezoelectric ceramics with longitudinal piezoelectric constant (d ) close to 2000 pC N , which combines single crystal-like high properties and ceramic-like cost effectiveness, large-scale manufacturing, and machinability will be a milestone in advancement of piezoelectric ceramic materials. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

A Convenient and Simple Ionic Polymer-Metal Composite (IPMC) Actuator Based on a Platinum-Coated Sulfonated Poly(ether ether ketone)-Polyaniline Composite Membrane.

Authors:
Mohammad Luqman Hamid M Shaikh Arfat Anis Saeed M Al-Zahrani Mohammad Asif Alam

Polymers (Basel) 2022 Feb 10;14(4). Epub 2022 Feb 10.

Center of Excellence for Research in Engineering Materials (CEREM), King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia.

Herein, we present new approaches for developing sulfonated polyether ether ketone (SPEEK) and polyaniline-based (PANI) actuator formed by film-casting and chemical reduction of Pt electrodes. We have thoroughly studied the synthesis of SPEEK and characterized it by different analytical techniques. The ion-exchange capacity (IEC) and proton conductivity of SPEEK-PANI polymer membrane were calculated to be 1. Read More

View Article and Full-Text PDF
February 2022
Similar Publications

A programmable and skin temperature-activated electromechanical synergistic dressing for effective wound healing.

Authors:
Guang Yao Xiaoyi Mo Chenhui Yin Wenhao Lou Qian Wang Sirong Huang Linna Mao Sihong Chen Kangning Zhao Taisong Pan Lin Huang Yuan Lin

Sci Adv 2022 Jan 26;8(4):eabl8379. Epub 2022 Jan 26.

School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.

Mechanical regulation and electric stimulation hold great promise in skin tissue engineering for manipulating wound healing. However, the complexity of equipment operation and stimulation implementation remains an ongoing challenge in clinical applications. Here, we propose a programmable and skin temperature-activated electromechanical synergistic wound dressing composed of a shape memory alloy-based mechanical metamaterial for wound contraction and an antibacterial electret thin film for electric field generation. Read More

View Article and Full-Text PDF
January 2022
Similar Publications
}
© 2022 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap