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Peptides as a therapeutic strategy against Klebsiella pneumoniae.

Authors:
Camila Maurmann de Souza Állan Pires da Silva Nelson Gomes Oliveira Júnior Osmel Fleitas Martínez Octávio Luiz Franco

Trends Pharmacol Sci 2022 04 22;43(4):335-348. Epub 2022 Jan 22.

Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brazil, 70790-160, Brazil; S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande CEP 79.117-900, Brazil. Electronic address:

Increasing levels of resistance to conventional antibiotics have led to a search for new therapeutic options against bacterial infections. Klebsiella pneumoniae is considered a world health problem due to high levels of mortality associated with resistance to multiple antibiotics. Antimicrobial peptides (AMPs) have showed activity against this bacterium, which makes them a promising alternative in tackling resistance. In this article, we carried out an overview of the recent development of AMPs against K. pneumoniae using different designs and acting by different mechanisms, such as a recently proposed one against capsulated strains. Moreover, we outline AMPs' therapeutic potential when tested in combination with conventional antibiotics and against biofilms. Furthermore, challenges and perspectives for applying AMPs in clinical practice are discussed here.

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http://dx.doi.org/10.1016/j.tips.2021.12.006DOI Listing
April 2022

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